18 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	XBP1	BZIP domain-containing protein. (412 aa)
	AICDA	Activation induced cytidine deaminase. (201 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	CD38	Uncharacterized protein. (45 aa)
	TLR6	Toll-like receptor. (797 aa)
	TLR1	Toll-like receptor. (796 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	AIRE	Autoimmune regulator. (440 aa)
	PAX5	Paired box 5. (391 aa)
	RAG2	Recombination activating 2. (527 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	FOXP3	Fork-head domain-containing protein. (474 aa)
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	DCLRE1C	DNA cross-link repair 1C. (693 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	TG	Uncharacterized protein. (1683 aa)
	IRF4	Interferon regulatory factor 4. (453 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD38	ENSOARP00000002081	ENSOARP00000001486	Activation induced cytidine deaminase.	Uncharacterized protein.	0.672
AICDA	CD4	ENSOARP00000002081	ENSOARP00000006749	Activation induced cytidine deaminase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.832
AICDA	GAPDH	ENSOARP00000002081	ENSOARP00000008476	Activation induced cytidine deaminase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.401
AICDA	IRF4	ENSOARP00000002081	ENSOARP00000004079	Activation induced cytidine deaminase.	Interferon regulatory factor 4.	0.912
AICDA	PAX5	ENSOARP00000002081	ENSOARP00000012346	Activation induced cytidine deaminase.	Paired box 5.	0.897
AICDA	RAG1	ENSOARP00000002081	ENSOARP00000011201	Activation induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.586
AICDA	RAG2	ENSOARP00000002081	ENSOARP00000011219	Activation induced cytidine deaminase.	Recombination activating 2.	0.537
AICDA	TLR6	ENSOARP00000002081	ENSOARP00000000565	Activation induced cytidine deaminase.	Toll-like receptor.	0.446
AICDA	XBP1	ENSOARP00000002081	ENSOARP00000003151	Activation induced cytidine deaminase.	BZIP domain-containing protein.	0.794
AIRE	CD4	ENSOARP00000012667	ENSOARP00000006749	Autoimmune regulator.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.784
AIRE	FOXP3	ENSOARP00000012667	ENSOARP00000011020	Autoimmune regulator.	Fork-head domain-containing protein.	0.530
AIRE	RAG2	ENSOARP00000012667	ENSOARP00000011219	Autoimmune regulator.	Recombination activating 2.	0.501
CD38	AICDA	ENSOARP00000001486	ENSOARP00000002081	Uncharacterized protein.	Activation induced cytidine deaminase.	0.672
CD38	CD4	ENSOARP00000001486	ENSOARP00000006749	Uncharacterized protein.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.910
CD38	FOXP3	ENSOARP00000001486	ENSOARP00000011020	Uncharacterized protein.	Fork-head domain-containing protein.	0.629
CD38	IFNG	ENSOARP00000001486	ENSOARP00000002060	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.606
CD38	IRF4	ENSOARP00000001486	ENSOARP00000004079	Uncharacterized protein.	Interferon regulatory factor 4.	0.525
CD38	ITGAM	ENSOARP00000001486	ENSOARP00000009667	Uncharacterized protein.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.676
CD38	PAX5	ENSOARP00000001486	ENSOARP00000012346	Uncharacterized protein.	Paired box 5.	0.434
CD38	ZAP70	ENSOARP00000001486	ENSOARP00000014636	Uncharacterized protein.	Tyrosine-protein kinase.	0.459