STRINGSTRING
GPX3 GPX3 SPHK1 SPHK1 GPX7 GPX7 SOD2 SOD2 NOS1 NOS1 TRAF4 TRAF4 NOS3 NOS3 IFNG IFNG NOX1 NOX1 UGT1A1 UGT1A1 GPX2 GPX2 ARG2 ARG2 LOC101107359 LOC101107359 GPX6 GPX6 GPX5 GPX5 LOC101103784 LOC101103784 CASP8 CASP8 HMGCR HMGCR SP1 SP1 PPARG PPARG ICAM1 ICAM1 EDN1 EDN1 ARG1 ARG1 CYBA CYBA IL6 IL6 SPHK2 SPHK2 LOC101110449 LOC101110449 UGT3A2 UGT3A2 SELE SELE SNN SNN ESAM ESAM LOC101119393 LOC101119393 LOC101122788 LOC101122788 W5PHZ3_SHEEP W5PHZ3_SHEEP W5PHP3_SHEEP W5PHP3_SHEEP W5PHA1_SHEEP W5PHA1_SHEEP LOC101117764 LOC101117764 LOC101117163 LOC101117163 UGT2B7 UGT2B7 LOC101116729 LOC101116729 GPX8 GPX8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
SPHK1Sphingosine kinase 1. (459 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
TRAF4TNF receptor-associated factor. (454 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
NOX1NADPH oxidase 1. (593 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (435 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
ARG2Arginase. (354 aa)
LOC101107359Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
LOC101103784Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
SP1Sp1 transcription factor. (786 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ICAM1Ig-like domain-containing protein. (536 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)
ARG1Arginase. (352 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
SPHK2Sphingosine kinase 2. (654 aa)
LOC101110449UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (525 aa)
UGT3A2UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (523 aa)
SELEUncharacterized protein. (484 aa)
SNNStannin. (87 aa)
ESAMEndothelial cell adhesion molecule. (392 aa)
LOC101119393UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC101122788UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (526 aa)
W5PHZ3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (520 aa)
W5PHP3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
W5PHA1_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
LOC101117764UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
LOC101117163UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
UGT2B7UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC101116729UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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