6 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARG2	Arginase. (354 aa)
	ARG1	Arginase. (352 aa)
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	CD19	CD19 molecule. (565 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (161 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	CD4	ENSOARP00000014964	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.899
ARG1	IL2	ENSOARP00000014964	ENSOARP00000000019	Arginase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.484
ARG1	ITGAM	ENSOARP00000014964	ENSOARP00000009667	Arginase.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.694
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	CD4	ENSOARP00000022756	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.758
CD19	CD4	ENSOARP00000001799	ENSOARP00000006749	CD19 molecule.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.985
CD19	IL2	ENSOARP00000001799	ENSOARP00000000019	CD19 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.834
CD19	ITGAM	ENSOARP00000001799	ENSOARP00000009667	CD19 molecule.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.919
CD4	ARG1	ENSOARP00000006749	ENSOARP00000014964	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.899
CD4	ARG2	ENSOARP00000006749	ENSOARP00000022756	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.758
CD4	CD19	ENSOARP00000006749	ENSOARP00000001799	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	CD19 molecule.	0.985
CD4	IL2	ENSOARP00000006749	ENSOARP00000000019	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.991
CD4	ITGAM	ENSOARP00000006749	ENSOARP00000009667	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.930
IL2	ARG1	ENSOARP00000000019	ENSOARP00000014964	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	Arginase.	0.484
IL2	CD19	ENSOARP00000000019	ENSOARP00000001799	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	CD19 molecule.	0.834
IL2	CD4	ENSOARP00000000019	ENSOARP00000006749	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.991
IL2	ITGAM	ENSOARP00000000019	ENSOARP00000009667	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.695
ITGAM	ARG1	ENSOARP00000009667	ENSOARP00000014964	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Arginase.	0.694
ITGAM	CD19	ENSOARP00000009667	ENSOARP00000001799	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	CD19 molecule.	0.919