STRINGSTRING
H2AX H2AX DAZL DAZL SYCP3 SYCP3 RAD50 RAD50 AFP AFP MSH4 MSH4 CLGN CLGN RAD52 RAD52 MDC1 MDC1 TOPBP1 TOPBP1 PGK2 PGK2 USP26 USP26 ACTB ACTB BRCA1 BRCA1 TKTL1 TKTL1 SETX SETX GAPDH GAPDH TNP1 TNP1 SPO11 SPO11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
DAZLDeleted in azoospermia like. (258 aa)
SYCP3Synaptonemal complex protein 3. (225 aa)
RAD50Zinc-hook domain-containing protein. (1444 aa)
AFPAlpha fetoprotein. (610 aa)
MSH4MutS homolog 4. (935 aa)
CLGNCalmegin. (613 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
MDC1Mediator of DNA damage checkpoint 1. (1965 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1524 aa)
PGK2Phosphoglycerate kinase. (417 aa)
USP26Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (902 aa)
ACTBActin, cytoplasmic 1. (378 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa)
TKTL1Transketolase like 1. (622 aa)
SETXSenataxin. (2662 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
TNP1Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (55 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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