STRINGSTRING
ARG2 ARG2 IL1B IL1B SLC2A2 SLC2A2 LGALS15 LGALS15 SLC1A2 SLC1A2 PTGER2 PTGER2 HGF HGF TYK2 TYK2 IGF1 IGF1 ODC1 ODC1 HPGD HPGD IRF1 IRF1 SERPINA14 SERPINA14 IFNK IFNK ETS2 ETS2 PTGS1 PTGS1 ARG1 ARG1 STAT1 STAT1 SLC1A1 SLC1A1 IFNAR1 IFNAR1 IFNGR2 IFNGR2 HSD11B1 HSD11B1 IGFBP1 IGFBP1 PTGER3 PTGER3 SLC5A1 SLC5A1 TGFB2 TGFB2 PRLR PRLR SLC1A5 SLC1A5 SLC1A3 SLC1A3 MX1 MX1 IGF1R IGF1R SLC7A2 SLC7A2 STAT2 STAT2 PRL PRL SLC2A5 SLC2A5 CSH CSH IFNE IFNE LOC114112819 LOC114112819 LOC101103623 LOC101103623 CTSL CTSL FGF10 FGF10 LOC101109399 LOC101109399 CTSV CTSV LOC101120448 LOC101120448 W5PEP6_SHEEP W5PEP6_SHEEP W5PE04_SHEEP W5PE04_SHEEP MMP9 MMP9 PGR PGR PTGS2 PTGS2 OXTR OXTR IRF2 IRF2 AKR1B1 AKR1B1 CD4 CD4 SLC1A7 SLC1A7 PTGER1 PTGER1 SLC1A6 SLC1A6 OXT OXT GRP GRP MUC1 MUC1 B2M B2M ESR1 ESR1 PLAT PLAT HSD11B2 HSD11B2 SPP1 SPP1 TGFB3 TGFB3 NR3C1 NR3C1 IFNG IFNG LOC101107259 LOC101107259 WNT7A WNT7A IFNGR1 IFNGR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARG2Arginase. (354 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (523 aa)
LGALS15Galectin. (81 aa)
SLC1A2Amino acid transporter. (574 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (734 aa)
TYK2Tyrosine-protein kinase. (1161 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
ODC1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (268 aa)
IRF1Interferon regulatory factor. (322 aa)
SERPINA14Uterine milk protein; Belongs to the serpin family. UTMP subfamily. (429 aa)
IFNKInterferon kappa. (189 aa)
ETS2ETS proto-oncogene 2, transcription factor. (466 aa)
PTGS1Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. (593 aa)
ARG1Arginase. (352 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
SLC1A1Amino acid transporter. (524 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. (292 aa)
IGFBP1Uncharacterized protein. (274 aa)
PTGER3Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal ur [...] (257 aa)
SLC5A1Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (664 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (581 aa)
SLC1A5Amino acid transporter. (546 aa)
SLC1A3Amino acid transporter. (542 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity. (656 aa)
IGF1RTyrosine-protein kinase receptor. (1122 aa)
SLC7A2Solute carrier family 7 member 2. (666 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation, mammogenesis, mitogenesis and osmoregulation. (231 aa)
SLC2A5Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. (502 aa)
CSHChorionic somatomammotropin hormone. (239 aa)
IFNEInterferon epsilon. (193 aa)
LOC114112819Uncharacterized protein. (186 aa)
LOC101103623Uncharacterized protein. (186 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (341 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
LOC101109399Uncharacterized protein. (210 aa)
CTSVCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
LOC101120448Uncharacterized protein. (212 aa)
W5PEP6_SHEEPUncharacterized protein. (219 aa)
W5PE04_SHEEPUncharacterized protein. (229 aa)
MMP9Matrix metallopeptidase 9. (700 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (347 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (607 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
IRF2Interferon regulatory factor. (349 aa)
AKR1B1Aldo_ket_red domain-containing protein. (316 aa)
CD4T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
SLC1A7Amino acid transporter. (529 aa)
PTGER1G_PROTEIN_RECEP_F1_2 domain-containing protein. (120 aa)
SLC1A6Amino acid transporter. (580 aa)
OXTOxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (107 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (83 aa)
MUC1SEA domain-containing protein. (588 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
HSD11B2Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. (428 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (781 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC101107259Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (270 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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