20 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARG2	Arginase. (354 aa)
	RETN	Uncharacterized protein. (109 aa)
	NFIL3	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
	IRF4	Interferon regulatory factor 4. (453 aa)
	IL34	Interleukin 34. (243 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
	IRF7	Interferon regulatory factor 7. (485 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (575 aa)
	BATF3	Basic leucine zipper ATF-like transcription factor 3. (151 aa)
	CD24	Uncharacterized protein. (78 aa)
	IRF8	Interferon regulatory factor 8. (437 aa)
	ARG1	Arginase. (352 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	ID2	BHLH domain-containing protein. (149 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
	CLEC9A	C-type lectin domain containing 9A. (283 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	CSF1	ENSOARP00000014964	ENSOARP00000020785	Arginase.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.608
ARG1	CSF1R	ENSOARP00000014964	ENSOARP00000006821	Arginase.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.417
ARG1	CX3CR1	ENSOARP00000014964	ENSOARP00000015036	Arginase.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.569
ARG1	IL21	ENSOARP00000014964	ENSOARP00000019188	Arginase.	Interleukin; Belongs to the IL-15/IL-21 family.	0.495
ARG1	ITGAM	ENSOARP00000014964	ENSOARP00000009667	Arginase.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.694
ARG1	NOS2	ENSOARP00000014964	ENSOARP00000017986	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.981
ARG1	RETN	ENSOARP00000014964	ENSOARP00000002425	Arginase.	Uncharacterized protein.	0.744
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	NOS2	ENSOARP00000022756	ENSOARP00000017986	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.959
BATF3	CD24	ENSOARP00000011220	ENSOARP00000011879	Basic leucine zipper ATF-like transcription factor 3.	Uncharacterized protein.	0.505
BATF3	CLEC9A	ENSOARP00000011220	ENSOARP00000022588	Basic leucine zipper ATF-like transcription factor 3.	C-type lectin domain containing 9A.	0.880
BATF3	CSF1R	ENSOARP00000011220	ENSOARP00000006821	Basic leucine zipper ATF-like transcription factor 3.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.404
BATF3	CX3CR1	ENSOARP00000011220	ENSOARP00000015036	Basic leucine zipper ATF-like transcription factor 3.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.552
BATF3	ID2	ENSOARP00000011220	ENSOARP00000015757	Basic leucine zipper ATF-like transcription factor 3.	BHLH domain-containing protein.	0.586
BATF3	IRF4	ENSOARP00000011220	ENSOARP00000004079	Basic leucine zipper ATF-like transcription factor 3.	Interferon regulatory factor 4.	0.729
BATF3	IRF8	ENSOARP00000011220	ENSOARP00000012337	Basic leucine zipper ATF-like transcription factor 3.	Interferon regulatory factor 8.	0.852
BATF3	ITGAM	ENSOARP00000011220	ENSOARP00000009667	Basic leucine zipper ATF-like transcription factor 3.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.583
BATF3	NFIL3	ENSOARP00000011220	ENSOARP00000003574	Basic leucine zipper ATF-like transcription factor 3.	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]	0.651
BATF3	RBPJ	ENSOARP00000011220	ENSOARP00000008761	Basic leucine zipper ATF-like transcription factor 3.	Recombination signal binding protein for immunoglobulin kappa J region.	0.408