11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALK	Tyrosine-protein kinase receptor. (1012 aa)
	MYCN	MYCN proto-oncogene, bHLH transcription factor. (316 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
	ARG1	Arginase. (352 aa)
	PHOX2B	Uncharacterized protein. (116 aa)
	SLC6A1	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (606 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	GABRA3	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	TRAK1	Trafficking kinesin protein 1. (923 aa)
	LOC101107259	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	GAPDH	ENSOARP00000021070	ENSOARP00000008476	Tyrosine-protein kinase receptor.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.471
ALK	MYCN	ENSOARP00000021070	ENSOARP00000017676	Tyrosine-protein kinase receptor.	MYCN proto-oncogene, bHLH transcription factor.	0.750
ALK	PHOX2B	ENSOARP00000021070	ENSOARP00000014846	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.442
ARG1	GAPDH	ENSOARP00000014964	ENSOARP00000008476	Arginase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.663
ARG1	LOC101107259	ENSOARP00000014964	ENSOARP00000001565	Arginase.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.987
ARG1	OAT	ENSOARP00000014964	ENSOARP00000010783	Arginase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ARG1	ODC1	ENSOARP00000014964	ENSOARP00000016555	Arginase.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.981
GABRA3	SLC6A1	ENSOARP00000008953	ENSOARP00000013420	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.578
GAPDH	ALK	ENSOARP00000008476	ENSOARP00000021070	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Tyrosine-protein kinase receptor.	0.471
GAPDH	ARG1	ENSOARP00000008476	ENSOARP00000014964	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Arginase.	0.663
GAPDH	MYCN	ENSOARP00000008476	ENSOARP00000017676	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	MYCN proto-oncogene, bHLH transcription factor.	0.539
LOC101107259	ARG1	ENSOARP00000001565	ENSOARP00000014964	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Arginase.	0.987
LOC101107259	OAT	ENSOARP00000001565	ENSOARP00000010783	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.984
LOC101107259	ODC1	ENSOARP00000001565	ENSOARP00000016555	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.903
MYCN	ALK	ENSOARP00000017676	ENSOARP00000021070	MYCN proto-oncogene, bHLH transcription factor.	Tyrosine-protein kinase receptor.	0.750
MYCN	GAPDH	ENSOARP00000017676	ENSOARP00000008476	MYCN proto-oncogene, bHLH transcription factor.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.539
MYCN	PHOX2B	ENSOARP00000017676	ENSOARP00000014846	MYCN proto-oncogene, bHLH transcription factor.	Uncharacterized protein.	0.662
OAT	ARG1	ENSOARP00000010783	ENSOARP00000014964	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Arginase.	0.997
OAT	LOC101107259	ENSOARP00000010783	ENSOARP00000001565	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.984
OAT	ODC1	ENSOARP00000010783	ENSOARP00000016555	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.977