STRINGSTRING
RECQL4 RECQL4 GDF5 GDF5 ATM ATM AIRE AIRE NANOS2 NANOS2 FOXO3 FOXO3 EIF4ENIF1 EIF4ENIF1 LARS2 LARS2 POU5F1 POU5F1 BMP15 BMP15 MCM9 MCM9 FOXL2 FOXL2 CLPP CLPP NAIP NAIP PMM2 PMM2 CYB5A CYB5A DLX5 DLX5 LHCGR LHCGR DLX6 DLX6 FSHR FSHR DUSP22 DUSP22 CYB5B CYB5B ESR1 ESR1 HK3 HK3 NUPR1 NUPR1 PCDH11X PCDH11X W5NX19_SHEEP W5NX19_SHEEP DIAPH2 DIAPH2 EIF2B2 EIF2B2 BRSK1 BRSK1 STAR STAR HSD17B4 HSD17B4 NANOS1 NANOS1 WRN WRN KIT KIT AMH AMH TGFBR3 TGFBR3 EIF4E EIF4E KITLG KITLG DMC1 DMC1 SALL4 SALL4 AR AR CDKN1B CDKN1B EIF2B5 EIF2B5 INHA INHA EIF2B4 EIF2B4 LAMC1 LAMC1 HARS2 HARS2 SPO11 SPO11 STAG3 STAG3 ADAMTS19 ADAMTS19 AMHR2 AMHR2 FOXO4 FOXO4 GDF9 GDF9 SYCE1 SYCE1 SOX9 SOX9 PTEN PTEN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RECQL4RecQ like helicase 4. (1105 aa)
GDF5Growth differentiation factor 5. (490 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
AIREAutoimmune regulator. (440 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (999 aa)
LARS2Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (903 aa)
POU5F1POU domain protein. (360 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
FOXL2Fork-head domain-containing protein. (158 aa)
CLPPATP-dependent Clp protease proteolytic subunit. (272 aa)
NAIPNLR family apoptosis inhibitory protein. (1430 aa)
PMM2Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (246 aa)
CYB5ACytochrome b5; Belongs to the cytochrome b5 family. (134 aa)
DLX5Distal-less homeobox 5. (290 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. (700 aa)
DLX6Distal-less homeobox 6. (237 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity). (656 aa)
DUSP22Dual specificity phosphatase 22. (162 aa)
CYB5BCytochrome b5 type B; Belongs to the cytochrome b5 family. (153 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
HK3Hexokinase 3. (951 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
PCDH11XUncharacterized protein. (1022 aa)
W5NX19_SHEEPUncharacterized protein. (356 aa)
DIAPH2Diaphanous related formin 2. (980 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (354 aa)
BRSK1BR serine/threonine kinase 1. (694 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (737 aa)
NANOS1Nanos-type domain-containing protein; Belongs to the nanos family. (125 aa)
WRNWRN RecQ like helicase. (1406 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
AMHAMH_N domain-containing protein. (213 aa)
TGFBR3Transforming growth factor beta receptor 3. (857 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
KITLGSoluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
SALL4Spalt like transcription factor 4. (1004 aa)
ARAndrogen receptor. (881 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (671 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (565 aa)
LAMC1Laminin subunit gamma 1. (1610 aa)
HARS2Histidyl-tRNA synthetase 2, mitochondrial. (586 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
STAG3Stromal antigen 3. (1275 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19. (1004 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (556 aa)
FOXO4Forkhead box O4. (476 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
SYCE1Synaptonemal complex central element protein 1. (323 aa)
SOX9SRY-box transcription factor 9. (383 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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