34 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELOB	Elongin B. (118 aa)
	MAVS	Mitochondrial antiviral signaling protein. (527 aa)
	TRAF2-2	MATH domain-containing protein. (215 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1039 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	ISG15	Uncharacterized protein. (166 aa)
	UBA6	Ubiquitin like modifier activating enzyme 6. (1057 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1507 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (718 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (112 aa)
	NFX1	Nuclear transcription factor, X-box binding 1. (1117 aa)
	DAXX	Death domain associated protein. (762 aa)
	PLP2	Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium. (146 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	SAE1	SUMO1 activating enzyme subunit 1. (346 aa)
	W5PN98_SHEEP	Small ubiquitin-related modifier. (95 aa)
	DDB1	Damage specific DNA binding protein 1. (1151 aa)
	UBL3	Ubiquitin-like protein. (122 aa)
	SUMO3	Small ubiquitin-related modifier. (104 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (959 aa)
	IRF3	Interferon regulatory factor 3. (411 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (490 aa)
	UBA1	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1059 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	RNF4	Ring finger protein 4. (194 aa)
	SMUG1	Uncharacterized protein. (144 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (748 aa)
	TSC2	TSC complex subunit 2. (1811 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (713 aa)
	RBX1	Ring-box 1. (112 aa)
	ATRX	ATRX chromatin remodeler. (2451 aa)
	CUL1	CULLIN_2 domain-containing protein; Belongs to the cullin family. (759 aa)
	SP100	SP100 nuclear antigen. (841 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	DAXX	ENSOARP00000019998	ENSOARP00000010217	ATRX chromatin remodeler.	Death domain associated protein.	0.999
ATRX	SP100	ENSOARP00000019998	ENSOARP00000022199	ATRX chromatin remodeler.	SP100 nuclear antigen.	0.777
ATRX	SUMO1	ENSOARP00000019998	ENSOARP00000018840	ATRX chromatin remodeler.	Small ubiquitin-related modifier.	0.600
ATRX	SUMO3	ENSOARP00000019998	ENSOARP00000013161	ATRX chromatin remodeler.	Small ubiquitin-related modifier.	0.550
ATRX	W5PN98_SHEEP	ENSOARP00000019998	ENSOARP00000011924	ATRX chromatin remodeler.	Small ubiquitin-related modifier.	0.628
CD4	CDA	ENSOARP00000006749	ENSOARP00000009878	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.460
CD4	CUL1	ENSOARP00000006749	ENSOARP00000020109	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.956
CD4	CUL5	ENSOARP00000006749	ENSOARP00000011663	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Cullin 5; Belongs to the cullin family.	0.583
CD4	DCAF1	ENSOARP00000006749	ENSOARP00000008103	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	DDB1 and CUL4 associated factor 1.	0.470
CD4	ELOB	ENSOARP00000006749	ENSOARP00000000332	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Elongin B.	0.509
CD4	IRF3	ENSOARP00000006749	ENSOARP00000014293	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interferon regulatory factor 3.	0.795
CD4	ISG15	ENSOARP00000006749	ENSOARP00000007752	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Uncharacterized protein.	0.689
CD4	MAVS	ENSOARP00000006749	ENSOARP00000000974	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Mitochondrial antiviral signaling protein.	0.620
CD4	RBX1	ENSOARP00000006749	ENSOARP00000019147	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Ring-box 1.	0.917
CD4	STAT1	ENSOARP00000006749	ENSOARP00000014920	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.903
CDA	CD4	ENSOARP00000009878	ENSOARP00000006749	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.460
CDA	CUL5	ENSOARP00000009878	ENSOARP00000011663	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Cullin 5; Belongs to the cullin family.	0.563
CDA	ELOB	ENSOARP00000009878	ENSOARP00000000332	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Elongin B.	0.502
CDA	SMUG1	ENSOARP00000009878	ENSOARP00000017462	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.543
CDT1	CUL1	ENSOARP00000014482	ENSOARP00000020109	Chromatin licensing and DNA replication factor 1.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.609