42 items (Ovis aries) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	FAS	Fas cell surface death receptor. (326 aa)
	W5PE04_SHEEP	Uncharacterized protein. (229 aa)
	MMP9	Matrix metallopeptidase 9. (700 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (347 aa)
	GNRHR	Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	OXTR	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	AR	Androgen receptor. (881 aa)
	ESR2	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily. (527 aa)
	CYP19	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (424 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	FSHB	Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (129 aa)
	SYCP3	Synaptonemal complex protein 3. (225 aa)
	GATA4	GATA binding protein 4. (346 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	CDK4	Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa)
	OXT	Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (107 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (411 aa)
	TH	Tyrosine hydroxylase. (441 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
	BCL2L1	Bcl-x long protein. (233 aa)
	KDR	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	W5NRI1_SHEEP	A2M_N_2 domain-containing protein. (680 aa)
	AMH	AMH_N domain-containing protein. (213 aa)
	GDF9	Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
	IGFBP1	Uncharacterized protein. (274 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1122 aa)
	HOXA10	Homeobox A10. (413 aa)
	BMP15	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
	PRL	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation, mammogenesis, mitogenesis and osmoregulation. (231 aa)
	CSH	Chorionic somatomammotropin hormone. (239 aa)
	LOC101109399	Uncharacterized protein. (210 aa)
	LOC101120448	Uncharacterized protein. (212 aa)
	LTBR	Lymphotoxin beta receptor. (401 aa)
	W5PEP6_SHEEP	Uncharacterized protein. (219 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	AR	ENSOARP00000015429	ENSOARP00000015583	AMH_N domain-containing protein.	Androgen receptor.	0.852
AMH	BMP15	ENSOARP00000015429	ENSOARP00000010055	AMH_N domain-containing protein.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.929
AMH	CYP19	ENSOARP00000015429	ENSOARP00000022542	AMH_N domain-containing protein.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.919
AMH	ESR1	ENSOARP00000015429	ENSOARP00000003565	AMH_N domain-containing protein.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.666
AMH	ESR2	ENSOARP00000015429	ENSOARP00000022731	AMH_N domain-containing protein.	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.781
AMH	FSHB	ENSOARP00000015429	ENSOARP00000016546	AMH_N domain-containing protein.	Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.	0.616
AMH	GATA4	ENSOARP00000015429	ENSOARP00000016334	AMH_N domain-containing protein.	GATA binding protein 4.	0.492
AMH	GDF9	ENSOARP00000015429	ENSOARP00000014175	AMH_N domain-containing protein.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.940
AMH	IGF1	ENSOARP00000015429	ENSOARP00000017024	AMH_N domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.654
AMH	PGR	ENSOARP00000015429	ENSOARP00000008411	AMH_N domain-containing protein.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.429
AMH	PRL	ENSOARP00000015429	ENSOARP00000009811	AMH_N domain-containing protein.	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation, mammogenesis, mitogenesis and osmoregulation.	0.414
AMH	SYCP3	ENSOARP00000015429	ENSOARP00000016365	AMH_N domain-containing protein.	Synaptonemal complex protein 3.	0.527
AR	AMH	ENSOARP00000015583	ENSOARP00000015429	Androgen receptor.	AMH_N domain-containing protein.	0.852
AR	CASP3	ENSOARP00000015583	ENSOARP00000008016	Androgen receptor.	Caspase 3; Belongs to the peptidase C14A family.	0.590
AR	CCND2	ENSOARP00000015583	ENSOARP00000011102	Androgen receptor.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.433
AR	CDK4	ENSOARP00000015583	ENSOARP00000005709	Androgen receptor.	Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]	0.449
AR	CYP19	ENSOARP00000015583	ENSOARP00000022542	Androgen receptor.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.763
AR	ESR1	ENSOARP00000015583	ENSOARP00000003565	Androgen receptor.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.661
AR	ESR2	ENSOARP00000015583	ENSOARP00000022731	Androgen receptor.	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.500
AR	GDF9	ENSOARP00000015583	ENSOARP00000014175	Androgen receptor.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.443