STRINGSTRING
STAT3 STAT3 GAP43 GAP43 SPP1 SPP1 BCAN BCAN STMN1 STMN1 MAG MAG NOS1 NOS1 OMG OMG SOCS3 SOCS3 LOC101114841 LOC101114841 GDF10 GDF10 NOS2 NOS2 IGF1 IGF1 SOX11 SOX11 PTEN PTEN ARG1 ARG1 HSPB1 HSPB1 W5PRT8_SHEEP W5PRT8_SHEEP VIM VIM CNTF CNTF STMN3 STMN3 ATF3 ATF3 STMN4 STMN4 MARCKS MARCKS STMN2 STMN2 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (825 aa)
GAP43Growth associated protein 43. (192 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa)
BCANBrevican. (914 aa)
STMN1Stathmin; Belongs to the stathmin family. (149 aa)
MAGMyelin associated glycoprotein. (667 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
LOC101114841Uncharacterized protein; Belongs to the parvalbumin family. (128 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
SOX11Transcription factor SOX. (419 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ARG1Arginase. (352 aa)
HSPB1Heat shock protein family B (small) member 1. (184 aa)
W5PRT8_SHEEPStathmin; Belongs to the stathmin family. (149 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (467 aa)
CNTFCiliary neurotrophic factor. (199 aa)
STMN3Stathmin; Belongs to the stathmin family. (180 aa)
ATF3Activating transcription factor 3. (187 aa)
STMN4Stathmin; Belongs to the stathmin family. (189 aa)
MARCKSUncharacterized protein. (77 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
BCL2BCL2 apoptosis regulator. (139 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (40%) [HD]