STRINGSTRING
SKP2 SKP2 CUL5 CUL5 UBA3 UBA3 STAT2 STAT2 CRBN CRBN CUL4A CUL4A CCNO CCNO NCK1 NCK1 STAT6 STAT6 DCAF1 DCAF1 UBA6 UBA6 ELOC ELOC CUL9 CUL9 SPOP SPOP DDB2 DDB2 CUL7 CUL7 NAE1 NAE1 CAND1 CAND1 STAT3 STAT3 ELOB ELOB CUL3 CUL3 ARIH1 ARIH1 STAT5B STAT5B UBE2F UBE2F CUL1 CUL1 RBX1 RBX1 CUL2 CUL2 SAMHD1 SAMHD1 KEAP1 KEAP1 METAP2 METAP2 SOCS2 SOCS2 HTT HTT STAT1 STAT1 UBA1 UBA1 CUL4B CUL4B SMC5 SMC5 DDB1 DDB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP2F-box domain-containing protein. (476 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (478 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
CRBNCereblon. (449 aa)
CUL4ACullin 4A; Belongs to the cullin family. (718 aa)
CCNOCyclin O; Belongs to the cyclin family. (272 aa)
NCK1Cytoplasmic protein. (377 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1057 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (249 aa)
CUL9Cullin 9; Belongs to the cullin family. (2522 aa)
SPOPSpeckle type BTB/POZ protein. (375 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
CUL7Cullin 7; Belongs to the cullin family. (1698 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
CAND1Cullin associated and neddylation dissociated 1. (1230 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
ELOBElongin B. (118 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
ARIH1RBR-type E3 ubiquitin transferase. (512 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
UBE2FUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
CUL1CULLIN_2 domain-containing protein; Belongs to the cullin family. (759 aa)
RBX1Ring-box 1. (112 aa)
CUL2Cullin 2; Belongs to the cullin family. (748 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (617 aa)
KEAP1Kelch like ECH associated protein 1. (615 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (478 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
HTTUncharacterized protein. (3051 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
UBA1Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1059 aa)
CUL4BCullin 4B; Belongs to the cullin family. (959 aa)
SMC5SMC_N domain-containing protein. (1167 aa)
DDB1Damage specific DNA binding protein 1. (1151 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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