STRINGSTRING
CD19 CD19 TLR4 TLR4 IFNG IFNG ARG2 ARG2 CD86 CD86 CD80 CD80 CCR7 CCR7 CXCL1 CXCL1 ALB ALB CCL2 CCL2 ITGAM ITGAM CD40 CD40 CD4 CD4 IL2 IL2 TLR1 TLR1 TLR6 TLR6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD19CD19 molecule. (565 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
ARG2Arginase. (354 aa)
CD86Ig-like domain-containing protein. (338 aa)
CD80Uncharacterized protein. (309 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
CXCL1Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (75 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
CCL2C-C motif chemokine. (115 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
CD40CD40 molecule. (280 aa)
CD4T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (161 aa)
TLR1Toll-like receptor. (796 aa)
TLR6Toll-like receptor. (797 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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