(26 nodes) (2018) Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. network (Ovis aries)

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Your Input:
	FST	Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (344 aa)
	SKIL	SKI like proto-oncogene. (687 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	JDP2	Jun dimerization protein 2. (199 aa)
	CREBBP	CREB binding protein. (2315 aa)
	CALML5	Calmodulin like 5. (149 aa)
	USF2	Upstream transcription factor 2, c-fos interacting. (340 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
	PLD2	Phospholipase. (1068 aa)
	ARRB2	Arrestin beta 2. (409 aa)
	CDC42	Cell division cycle 42. (237 aa)
	USF1	BHLH domain-containing protein. (314 aa)
	TGIF1	TGFB induced factor homeobox 1. (406 aa)
	ATF3	Activating transcription factor 3. (187 aa)
	CALM3	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	RHO	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
	PITX1	Homeobox protein. (204 aa)
	FSHB	Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
	NAB1	NGFI-A binding protein 1. (488 aa)
	CALML4	Calmodulin like 4. (197 aa)
	OTX1	Orthodenticle homeobox 1. (355 aa)
	PLD1	Phospholipase. (1151 aa)
	LOC105614854	Uncharacterized protein; Belongs to the calmodulin family. (145 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSOARP00000012161	ENSOARP00000008370	Arrestin beta 1.	Arrestin beta 2.	0.936
ARRB1	CALM3	ENSOARP00000012161	ENSOARP00000011414	Arrestin beta 1.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.462
ARRB1	CALML4	ENSOARP00000012161	ENSOARP00000019762	Arrestin beta 1.	Calmodulin like 4.	0.460
ARRB1	CALML5	ENSOARP00000012161	ENSOARP00000004928	Arrestin beta 1.	Calmodulin like 5.	0.460
ARRB1	PRKACA	ENSOARP00000012161	ENSOARP00000006933	Arrestin beta 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.605
ARRB1	PRKACB	ENSOARP00000012161	ENSOARP00000014812	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.603
ARRB1	RHO	ENSOARP00000012161	ENSOARP00000015330	Arrestin beta 1.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.902
ARRB2	ARRB1	ENSOARP00000008370	ENSOARP00000012161	Arrestin beta 2.	Arrestin beta 1.	0.936
ARRB2	CALM3	ENSOARP00000008370	ENSOARP00000011414	Arrestin beta 2.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.464
ARRB2	CALML4	ENSOARP00000008370	ENSOARP00000019762	Arrestin beta 2.	Calmodulin like 4.	0.458
ARRB2	CALML5	ENSOARP00000008370	ENSOARP00000004928	Arrestin beta 2.	Calmodulin like 5.	0.457
ARRB2	PRKACA	ENSOARP00000008370	ENSOARP00000006933	Arrestin beta 2.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.600
ARRB2	PRKACB	ENSOARP00000008370	ENSOARP00000014812	Arrestin beta 2.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.600
ARRB2	RHO	ENSOARP00000008370	ENSOARP00000015330	Arrestin beta 2.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.908
ATF3	CREBBP	ENSOARP00000011261	ENSOARP00000002661	Activating transcription factor 3.	CREB binding protein.	0.487
ATF3	JDP2	ENSOARP00000011261	ENSOARP00000001885	Activating transcription factor 3.	Jun dimerization protein 2.	0.459
ATF3	MAPK8	ENSOARP00000011261	ENSOARP00000001531	Activating transcription factor 3.	Mitogen-activated protein kinase.	0.554
CALM3	ARRB1	ENSOARP00000011414	ENSOARP00000012161	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Arrestin beta 1.	0.462
CALM3	ARRB2	ENSOARP00000011414	ENSOARP00000008370	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Arrestin beta 2.	0.464
CALM3	CALML4	ENSOARP00000011414	ENSOARP00000019762	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Calmodulin like 4.	0.963