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CAVIN3 CAVIN3 ARG2 ARG2 GRAP2 GRAP2 SOCS5 SOCS5 SOCS2 SOCS2 CAVIN2 CAVIN2 ARG1 ARG1 ALB ALB JAK2 JAK2 IL6 IL6 FLOT1 FLOT1 PRLR PRLR EHD2 EHD2 CNTF CNTF CUL5 CUL5 LEPR LEPR JAK1 JAK1 SOCS7 SOCS7 GAPDH GAPDH CAV3 CAV3 ELOC ELOC EPS15 EPS15 STAT3 STAT3 CAV1 CAV1 CUEDC2 CUEDC2 STAT5A STAT5A ELOB ELOB SOCS3 SOCS3 SRC SRC EPOR EPOR CSF3R CSF3R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAVIN3Caveolae associated protein 3. (271 aa)
ARG2Arginase. (354 aa)
GRAP2GRB2 related adaptor protein 2. (315 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
CAVIN2Caveolae associated protein 2. (464 aa)
ARG1Arginase. (352 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (581 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (590 aa)
CNTFCiliary neurotrophic factor. (199 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
LEPRUncharacterized protein. (1165 aa)
JAK1Tyrosine-protein kinase. (1161 aa)
SOCS7Suppressor of cytokine signaling 7. (493 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (249 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (912 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CUEDC2CUE domain containing 2. (269 aa)
STAT5ASignal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. (788 aa)
ELOBElongin B. (118 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
SRCTyrosine-protein kinase. (541 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (511 aa)
CSF3RColony stimulating factor 3 receptor. (843 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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