24 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	REC8	REC8 meiotic recombination protein. (592 aa)
	GDF3	Growth differentiation factor 3. (371 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. (700 aa)
	FOXL2	Fork-head domain-containing protein. (158 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (607 aa)
	MCM9	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
	TNFAIP6	TNF alpha induced protein 6. (280 aa)
	BMP15	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
	HAS2	Hyaluronan synthase 2. (558 aa)
	FIGLA	BHLH domain-containing protein. (166 aa)
	LHX8	LIM homeobox 8. (372 aa)
	FURIN	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (712 aa)
	GDF9	Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
	SYCE1	Synaptonemal complex central element protein 1. (323 aa)
	EGFR	Receptor protein-tyrosine kinase. (1155 aa)
	AMH	AMH_N domain-containing protein. (213 aa)
	AREG	Amphiregulin. (247 aa)
	KITLG	Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
	HFM1	Helicase for meiosis 1. (1434 aa)
	STAG3	Stromal antigen 3. (1275 aa)
	BMP6	Bone morphogenetic protein 6. (340 aa)
	BMP7	Bone morphogenetic protein 7. (397 aa)
	MCM8	MCM domain-containing protein; Belongs to the MCM family. (835 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	BMP15	ENSOARP00000015429	ENSOARP00000010055	AMH_N domain-containing protein.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.929
AMH	FIGLA	ENSOARP00000015429	ENSOARP00000012007	AMH_N domain-containing protein.	BHLH domain-containing protein.	0.531
AMH	FOXL2	ENSOARP00000015429	ENSOARP00000007704	AMH_N domain-containing protein.	Fork-head domain-containing protein.	0.858
AMH	GDF9	ENSOARP00000015429	ENSOARP00000014175	AMH_N domain-containing protein.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.940
AMH	KITLG	ENSOARP00000015429	ENSOARP00000016728	AMH_N domain-containing protein.	Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...]	0.663
AMH	LHCGR	ENSOARP00000015429	ENSOARP00000004768	AMH_N domain-containing protein.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.	0.885
AMH	LHX8	ENSOARP00000015429	ENSOARP00000013489	AMH_N domain-containing protein.	LIM homeobox 8.	0.505
AMH	SMAD2	ENSOARP00000015429	ENSOARP00000003900	AMH_N domain-containing protein.	Mothers against decapentaplegic homolog.	0.460
AREG	EGFR	ENSOARP00000016147	ENSOARP00000014758	Amphiregulin.	Receptor protein-tyrosine kinase.	0.998
AREG	HAS2	ENSOARP00000016147	ENSOARP00000011850	Amphiregulin.	Hyaluronan synthase 2.	0.528
AREG	LHCGR	ENSOARP00000016147	ENSOARP00000004768	Amphiregulin.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.	0.430
AREG	PTGS2	ENSOARP00000016147	ENSOARP00000008147	Amphiregulin.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.634
AREG	TNFAIP6	ENSOARP00000016147	ENSOARP00000009686	Amphiregulin.	TNF alpha induced protein 6.	0.600
BMP15	AMH	ENSOARP00000010055	ENSOARP00000015429	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	AMH_N domain-containing protein.	0.929
BMP15	FIGLA	ENSOARP00000010055	ENSOARP00000012007	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	BHLH domain-containing protein.	0.758
BMP15	FOXL2	ENSOARP00000010055	ENSOARP00000007704	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Fork-head domain-containing protein.	0.674
BMP15	FURIN	ENSOARP00000010055	ENSOARP00000013689	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.440
BMP15	GDF9	ENSOARP00000010055	ENSOARP00000014175	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.894
BMP15	HAS2	ENSOARP00000010055	ENSOARP00000011850	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Hyaluronan synthase 2.	0.640
BMP15	KITLG	ENSOARP00000010055	ENSOARP00000016728	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...]	0.654