42 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	ARG2	Arginase. (354 aa)
	GCH1	GTP cyclohydrolase 1. (254 aa)
	NCK2	NCK adaptor protein 2. (343 aa)
	AZIN2	Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (519 aa)
	IRS1	Insulin receptor substrate 1. (1189 aa)
	GSK3B	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	IRF9	Interferon regulatory factor 9. (462 aa)
	LGALS15	Galectin. (81 aa)
	MLST8	MTOR associated protein, LST8 homolog. (291 aa)
	TSC2	TSC complex subunit 2. (1811 aa)
	ILK	Uncharacterized protein. (452 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (734 aa)
	GLYCAM1	Uncharacterized protein. (154 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (363 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	ARG1	Arginase. (352 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	SLC7A1	AA_permease_C domain-containing protein. (319 aa)
	MX1	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity. (656 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1708 aa)
	AGMAT	Agmatinase; Belongs to the arginase family. (361 aa)
	STAT2	Signal transducer and activator of transcription. (849 aa)
	CTSL	Cathepsin L1; Belongs to the peptidase C1 family. (341 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	CTSV	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (347 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (607 aa)
	IRF2	Interferon regulatory factor. (349 aa)
	ISG15	Uncharacterized protein. (166 aa)
	TSC1	TSC complex subunit 1. (1160 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa)
	OXT	Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (107 aa)
	RHEB	Uncharacterized protein. (168 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
	CADM1	Cell adhesion molecule 1. (431 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGMAT	ARG1	ENSOARP00000010067	ENSOARP00000014964	Agmatinase; Belongs to the arginase family.	Arginase.	0.472
AGMAT	ARG2	ENSOARP00000010067	ENSOARP00000022756	Agmatinase; Belongs to the arginase family.	Arginase.	0.483
AGMAT	AZIN2	ENSOARP00000010067	ENSOARP00000022422	Agmatinase; Belongs to the arginase family.	Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.992
AGMAT	GCH1	ENSOARP00000010067	ENSOARP00000022652	Agmatinase; Belongs to the arginase family.	GTP cyclohydrolase 1.	0.416
AGMAT	NOS3	ENSOARP00000010067	ENSOARP00000002091	Agmatinase; Belongs to the arginase family.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.436
AGMAT	OAT	ENSOARP00000010067	ENSOARP00000010783	Agmatinase; Belongs to the arginase family.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.910
AGMAT	ODC1	ENSOARP00000010067	ENSOARP00000016555	Agmatinase; Belongs to the arginase family.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.987
AGMAT	SLC7A1	ENSOARP00000010067	ENSOARP00000012895	Agmatinase; Belongs to the arginase family.	AA_permease_C domain-containing protein.	0.719
ARG1	AGMAT	ENSOARP00000014964	ENSOARP00000010067	Arginase.	Agmatinase; Belongs to the arginase family.	0.472
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	AZIN2	ENSOARP00000014964	ENSOARP00000022422	Arginase.	Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.972
ARG1	NOS3	ENSOARP00000014964	ENSOARP00000002091	Arginase.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.448
ARG1	OAT	ENSOARP00000014964	ENSOARP00000010783	Arginase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ARG1	ODC1	ENSOARP00000014964	ENSOARP00000016555	Arginase.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.981
ARG1	PTGS2	ENSOARP00000014964	ENSOARP00000008147	Arginase.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.553
ARG2	AGMAT	ENSOARP00000022756	ENSOARP00000010067	Arginase.	Agmatinase; Belongs to the arginase family.	0.483
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	AZIN2	ENSOARP00000022756	ENSOARP00000022422	Arginase.	Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.977
ARG2	GCH1	ENSOARP00000022756	ENSOARP00000022652	Arginase.	GTP cyclohydrolase 1.	0.415
ARG2	NOS3	ENSOARP00000022756	ENSOARP00000002091	Arginase.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.584