STRINGSTRING
ZNF775 ZNF775 CES3 CES3 CD163 CD163 BCL2 BCL2 HOGA1 HOGA1 PDXK PDXK MGST3 MGST3 ATM ATM UQCRQ UQCRQ TMEM120A TMEM120A HAGHL HAGHL ALB ALB ARG1 ARG1 MYOZ2 MYOZ2 DCXR DCXR GPD1 GPD1 TNNI1 TNNI1 NDUFA6 NDUFA6 ACTC1 ACTC1 MCHR1 MCHR1 ARG2 ARG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF775Uncharacterized protein. (121 aa)
CES3Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
CD163CD163 molecule. (1136 aa)
BCL2BCL2 apoptosis regulator. (139 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
PDXKPyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. (285 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
TMEM120ATransmembrane protein 120A. (341 aa)
HAGHLHydroxyacylglutathione hydrolase like. (290 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
ARG1Arginase. (352 aa)
MYOZ2Myozenin 2. (264 aa)
DCXRUncharacterized protein. (244 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
NDUFA6NADH:ubiquinone oxidoreductase subunit A6; Belongs to the complex I LYR family. (140 aa)
ACTC1Actin alpha cardiac muscle 1. (378 aa)
MCHR1Melanin concentrating hormone receptor 1. (341 aa)
ARG2Arginase. (354 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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