STRINGSTRING
CD163 CD163 RBP4 RBP4 LOC101102413 LOC101102413 LOC101121993 LOC101121993 CP CP IL10 IL10 TTR TTR CRP CRP IL6 IL6 ITGB2 ITGB2 ALB ALB SERPINA1 SERPINA1 HMOX1 HMOX1 LBP LBP W5QC18_SHEEP W5QC18_SHEEP IL1RN IL1RN IL1F10 IL1F10 IL36RN IL36RN IL36B IL36B IL36A IL36A IL36G IL36G IL37 IL37
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD163CD163 molecule. (1136 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (165 aa)
LOC101102413Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
LOC101121993Uncharacterized protein; Belongs to the multicopper oxidase family. (1043 aa)
CPCeruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (By similarity). (1061 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (147 aa)
CRPPentaxin. (224 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (750 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
SERPINA1Alpha-1-antiproteinase; Inhibits human leukocyte elastase, pig pancreatic elastase and bovine trypsin on a 1:1 molar basis; Belongs to the serpin family. (416 aa)
HMOX1Heme oxygenase 1. (271 aa)
LBPLipopolysaccharide binding protein. (540 aa)
W5QC18_SHEEPUncharacterized protein. (482 aa)
IL1RNInterleukin-1. (174 aa)
IL1F10Interleukin-1. (157 aa)
IL36RNInterleukin-1. (156 aa)
IL36BInterleukin-1. (154 aa)
IL36AInterleukin-1. (169 aa)
IL36GInterleukin-1. (120 aa)
IL37Interleukin-1. (218 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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