(25 nodes) (2018) Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. network (Ovis aries)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	RAB8A	RAB8A. (207 aa)
	IFT43	Intraflagellar transport 43. (207 aa)
	KIF3B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (752 aa)
	NUDC	Nuclear distribution C, dynein complex regulator. (331 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (698 aa)
	BBS9	Bardet-Biedl syndrome 9. (707 aa)
	SHH	Uncharacterized protein. (232 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	DYNLL2	Dynein light chain. (132 aa)
	TMEM67	Transmembrane protein 67. (999 aa)
	WDR34	Uncharacterized protein. (293 aa)
	DYNLRB1	Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (96 aa)
	IFT88	Intraflagellar transport 88. (834 aa)
	BBS7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	IFT74	Intraflagellar transport 74. (600 aa)
	NUDCD3	NudC domain containing 3. (359 aa)
	IFT140	Intraflagellar transport 140. (1474 aa)
	TCTN1	Tectonic family member 1. (622 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (418 aa)
	IFT20	Intraflagellar transport 20. (156 aa)
	RPGRIP1L	RPGRIP1 like. (1270 aa)
	IFT57	Intraflagellar transport 57. (428 aa)
	IFT172	Intraflagellar transport 172. (1751 aa)
	SSTR3	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (410 aa)
	TCTEX1D2	Uncharacterized protein. (146 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	BBS7	ENSOARP00000018611	ENSOARP00000014931	ADP ribosylation factor like GTPase 13B.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.409
ARL13B	DYNLL2	ENSOARP00000018611	ENSOARP00000008972	ADP ribosylation factor like GTPase 13B.	Dynein light chain.	0.587
ARL13B	IFT140	ENSOARP00000018611	ENSOARP00000017004	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 140.	0.686
ARL13B	IFT172	ENSOARP00000018611	ENSOARP00000020777	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 172.	0.869
ARL13B	IFT20	ENSOARP00000018611	ENSOARP00000018809	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 20.	0.890
ARL13B	IFT43	ENSOARP00000018611	ENSOARP00000002168	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 43.	0.636
ARL13B	IFT57	ENSOARP00000018611	ENSOARP00000020298	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 57.	0.813
ARL13B	IFT74	ENSOARP00000018611	ENSOARP00000015604	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 74.	0.706
ARL13B	IFT88	ENSOARP00000018611	ENSOARP00000014886	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 88.	0.920
ARL13B	KIF3B	ENSOARP00000018611	ENSOARP00000003705	ADP ribosylation factor like GTPase 13B.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.486
ARL13B	RAB8A	ENSOARP00000018611	ENSOARP00000000637	ADP ribosylation factor like GTPase 13B.	RAB8A.	0.790
ARL13B	RPGRIP1L	ENSOARP00000018611	ENSOARP00000019195	ADP ribosylation factor like GTPase 13B.	RPGRIP1 like.	0.848
ARL13B	SHH	ENSOARP00000018611	ENSOARP00000007435	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.714
ARL13B	SMO	ENSOARP00000018611	ENSOARP00000004538	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.889
ARL13B	SSTR3	ENSOARP00000018611	ENSOARP00000021710	ADP ribosylation factor like GTPase 13B.	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.662
ARL13B	TCTN1	ENSOARP00000018611	ENSOARP00000018435	ADP ribosylation factor like GTPase 13B.	Tectonic family member 1.	0.700
ARL13B	TMEM67	ENSOARP00000018611	ENSOARP00000009081	ADP ribosylation factor like GTPase 13B.	Transmembrane protein 67.	0.845
ARL13B	WDR34	ENSOARP00000018611	ENSOARP00000010439	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.579
BBS7	ARL13B	ENSOARP00000014931	ENSOARP00000018611	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	ADP ribosylation factor like GTPase 13B.	0.409
BBS7	BBS9	ENSOARP00000014931	ENSOARP00000006607	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Bardet-Biedl syndrome 9.	0.999