(7 nodes) (2018) The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs. network (Ovis aries)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLD2	Phospholipase. (1068 aa)
	CRP	Pentaxin. (224 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
	PLD1	Phospholipase. (1151 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (701 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (719 aa)
	W5NRI1_SHEEP	A2M_N_2 domain-containing protein. (680 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	C1S	ENSOARP00000014782	ENSOARP00000004994	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Complement C1s; Belongs to the peptidase S1 family.	0.567
ALB	CRP	ENSOARP00000014782	ENSOARP00000008383	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Pentaxin.	0.832
ALB	W5NRI1_SHEEP	ENSOARP00000014782	ENSOARP00000000771	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	A2M_N_2 domain-containing protein.	0.648
C1R	C1S	ENSOARP00000004838	ENSOARP00000004994	Complement C1r; Belongs to the peptidase S1 family.	Complement C1s; Belongs to the peptidase S1 family.	0.999
C1R	CRP	ENSOARP00000004838	ENSOARP00000008383	Complement C1r; Belongs to the peptidase S1 family.	Pentaxin.	0.622
C1R	W5NRI1_SHEEP	ENSOARP00000004838	ENSOARP00000000771	Complement C1r; Belongs to the peptidase S1 family.	A2M_N_2 domain-containing protein.	0.566
C1S	ALB	ENSOARP00000004994	ENSOARP00000014782	Complement C1s; Belongs to the peptidase S1 family.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.567
C1S	C1R	ENSOARP00000004994	ENSOARP00000004838	Complement C1s; Belongs to the peptidase S1 family.	Complement C1r; Belongs to the peptidase S1 family.	0.999
C1S	CRP	ENSOARP00000004994	ENSOARP00000008383	Complement C1s; Belongs to the peptidase S1 family.	Pentaxin.	0.574
C1S	W5NRI1_SHEEP	ENSOARP00000004994	ENSOARP00000000771	Complement C1s; Belongs to the peptidase S1 family.	A2M_N_2 domain-containing protein.	0.620
CRP	ALB	ENSOARP00000008383	ENSOARP00000014782	Pentaxin.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.832
CRP	C1R	ENSOARP00000008383	ENSOARP00000004838	Pentaxin.	Complement C1r; Belongs to the peptidase S1 family.	0.622
CRP	C1S	ENSOARP00000008383	ENSOARP00000004994	Pentaxin.	Complement C1s; Belongs to the peptidase S1 family.	0.574
CRP	W5NRI1_SHEEP	ENSOARP00000008383	ENSOARP00000000771	Pentaxin.	A2M_N_2 domain-containing protein.	0.465
PLD1	PLD2	ENSOARP00000022308	ENSOARP00000007184	Phospholipase.	Phospholipase.	0.904
PLD2	PLD1	ENSOARP00000007184	ENSOARP00000022308	Phospholipase.	Phospholipase.	0.904
W5NRI1_SHEEP	ALB	ENSOARP00000000771	ENSOARP00000014782	A2M_N_2 domain-containing protein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.648
W5NRI1_SHEEP	C1R	ENSOARP00000000771	ENSOARP00000004838	A2M_N_2 domain-containing protein.	Complement C1r; Belongs to the peptidase S1 family.	0.566
W5NRI1_SHEEP	C1S	ENSOARP00000000771	ENSOARP00000004994	A2M_N_2 domain-containing protein.	Complement C1s; Belongs to the peptidase S1 family.	0.620
W5NRI1_SHEEP	CRP	ENSOARP00000000771	ENSOARP00000008383	A2M_N_2 domain-containing protein.	Pentaxin.	0.465