29 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
	SLC7A7	Solute carrier family 7 member 7. (511 aa)
	GCH1	GTP cyclohydrolase 1. (254 aa)
	ERAP2	Aminopeptidase. (968 aa)
	ERAP1	Aminopeptidase. (942 aa)
	SLC3A2	Solute carrier family 3 member 2. (577 aa)
	ARG2	Arginase. (354 aa)
	LOC101107259	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	ENPEP	Aminopeptidase. (953 aa)
	LVRN	Aminopeptidase. (985 aa)
	SLC1A6	Amino acid transporter. (580 aa)
	SLC1A7	Amino acid transporter. (529 aa)
	ASS1	Argininosuccinate synthase 1. (410 aa)
	NPEPPS	Aminopeptidase. (827 aa)
	SLC7A2	Solute carrier family 7 member 2. (666 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	SLC1A3	Amino acid transporter. (542 aa)
	SLC1A5	Amino acid transporter. (546 aa)
	ANPEP	Aminopeptidase. (968 aa)
	SLC1A1	Amino acid transporter. (524 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	ARG1	Arginase. (352 aa)
	TRHDE	Aminopeptidase. (871 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	ENPEP	ENSOARP00000012699	ENSOARP00000003978	Aminopeptidase.	Aminopeptidase.	0.438
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	ASS1	ENSOARP00000014964	ENSOARP00000008253	Arginase.	Argininosuccinate synthase 1.	0.601
ARG1	CSF1	ENSOARP00000014964	ENSOARP00000020785	Arginase.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.608
ARG1	IFNG	ENSOARP00000014964	ENSOARP00000002060	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.810
ARG1	IL4	ENSOARP00000014964	ENSOARP00000015980	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.882
ARG1	LOC101107259	ENSOARP00000014964	ENSOARP00000001565	Arginase.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.987
ARG1	OAT	ENSOARP00000014964	ENSOARP00000010783	Arginase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ARG1	ODC1	ENSOARP00000014964	ENSOARP00000016555	Arginase.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.981
ARG1	SLC7A2	ENSOARP00000014964	ENSOARP00000009951	Arginase.	Solute carrier family 7 member 2.	0.462
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	ASS1	ENSOARP00000022756	ENSOARP00000008253	Arginase.	Argininosuccinate synthase 1.	0.610
ARG2	GCH1	ENSOARP00000022756	ENSOARP00000022652	Arginase.	GTP cyclohydrolase 1.	0.415
ARG2	IFNG	ENSOARP00000022756	ENSOARP00000002060	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.649
ARG2	IL4	ENSOARP00000022756	ENSOARP00000015980	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.661
ARG2	LOC101107259	ENSOARP00000022756	ENSOARP00000001565	Arginase.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.990
ARG2	OAT	ENSOARP00000022756	ENSOARP00000010783	Arginase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ARG2	ODC1	ENSOARP00000022756	ENSOARP00000016555	Arginase.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.982
ARG2	SLC1A1	ENSOARP00000022756	ENSOARP00000014363	Arginase.	Amino acid transporter.	0.410
ARG2	SLC1A5	ENSOARP00000022756	ENSOARP00000011566	Arginase.	Amino acid transporter.	0.429