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KDM5B KDM5B EMX2 EMX2 REC8 REC8 PRMT5 PRMT5 ETV5 ETV5 SETDB1 SETDB1 BMP4 BMP4 SIX1 SIX1 FGF9 FGF9 NR5A1 NR5A1 GDF9 GDF9 DMRT1 DMRT1 MSH4 MSH4 LHX8 LHX8 TET3 TET3 ATM ATM DNMT3L DNMT3L CYP26B1 CYP26B1 NANOS2 NANOS2 FOXO3 FOXO3 TET2 TET2 PAX7 PAX7 CXCR4 CXCR4 GDNF GDNF BCL6B BCL6B EVX1 EVX1 BMP15 BMP15 FST FST WNT4 WNT4 CASP3 CASP3 FOXL2 FOXL2 HOXB1 HOXB1 FOXO1 FOXO1 NEUROG3 NEUROG3 TET1 TET1 SMAD4 SMAD4 PRDM14 PRDM14 CBX2 CBX2 BMI1 BMI1 DNMT3A DNMT3A MAP2K1 MAP2K1 SPO11 SPO11 INHBA INHBA FGF8 FGF8 GFRA1 GFRA1 DMC1 DMC1 DAZL DAZL LHX9 LHX9 DNMT1 DNMT1 SYCP3 SYCP3 SMAD5 SMAD5 SALL4 SALL4 EOMES EOMES AMH AMH PTEN PTEN SOX9 SOX9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDM5BLysine demethylase 5B. (1496 aa)
EMX2Empty spiracles homeobox 2. (291 aa)
REC8REC8 meiotic recombination protein. (592 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
ETV5ETS variant 5. (551 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
SIX1Homeobox domain-containing protein. (355 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (439 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (332 aa)
MSH4MutS homolog 4. (935 aa)
LHX8LIM homeobox 8. (372 aa)
TET3Tet methylcytosine dioxygenase 3. (1663 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
DNMT3LPHD-type domain-containing protein. (420 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
TET2Tet methylcytosine dioxygenase 2. (2020 aa)
PAX7Paired box 7. (501 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
GDNFGlial cell derived neurotrophic factor. (230 aa)
BCL6BBCL6B transcription repressor. (473 aa)
EVX1Even-skipped homeobox 1. (376 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
FSTFollistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (344 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (300 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
FOXL2Fork-head domain-containing protein. (158 aa)
HOXB1Homeobox B1. (302 aa)
FOXO1Fork-head domain-containing protein. (445 aa)
NEUROG3Neurogenin 3. (207 aa)
TET1Tet methylcytosine dioxygenase 1. (2138 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PRDM14PR/SET domain 14. (491 aa)
CBX2Chromobox 2. (541 aa)
BMI1RING-type domain-containing protein. (326 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (948 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GFRA1GDNF family receptor alpha 1. (335 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
DAZLDeleted in azoospermia like. (258 aa)
LHX9LIM homeobox 9. (402 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1733 aa)
SYCP3Synaptonemal complex protein 3. (225 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SALL4Spalt like transcription factor 4. (1004 aa)
EOMESEomesodermin. (620 aa)
AMHAMH_N domain-containing protein. (213 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SOX9SRY-box transcription factor 9. (383 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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