STRINGSTRING
TLR2 TLR2 ADAM23 ADAM23 CNTN1 CNTN1 HYAL4 HYAL4 STAT3 STAT3 CSPG4 CSPG4 LOXL1 LOXL1 ITGBL1 ITGBL1 COL4A1 COL4A1 BCAN BCAN COL21A1 COL21A1 CLSTN1 CLSTN1 ITGAD ITGAD LGALS1 LGALS1 SOX2 SOX2 ITGB1BP1 ITGB1BP1 SERPINE1 SERPINE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ADAM23ADAM metallopeptidase domain 23. (811 aa)
CNTN1Contactin 1. (1026 aa)
HYAL4Hyaluronidase. (481 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2320 aa)
LOXL1Lysyl oxidase like 1. (581 aa)
ITGBL1Integrin subunit beta like 1. (392 aa)
COL4A1Collagen type IV alpha 1 chain. (1574 aa)
BCANBrevican. (914 aa)
COL21A1Collagen type XXI alpha 1 chain. (959 aa)
CLSTN1Calsyntenin 1. (1034 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1160 aa)
LGALS1Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase (By similarity). Strong inducer of T-cell apoptosis. (108 aa)
SOX2Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses n [...] (293 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (204 aa)
SERPINE1SERPIN domain-containing protein; Belongs to the serpin family. (402 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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