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NFKBIA | ANK_REP_REGION domain-containing protein. (311 aa) | ||||
TLR1 | Toll-like receptor. (796 aa) | ||||
TLR6 | Toll-like receptor. (797 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) | ||||
TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) | ||||
MAP2K7 | Protein kinase domain-containing protein. (613 aa) | ||||
RAB7A | RAS oncogene family-like 7A. (207 aa) | ||||
SOD2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa) | ||||
SLC1A6 | Amino acid transporter. (580 aa) | ||||
LMNA | Lamin A/C; Belongs to the intermediate filament family. (658 aa) | ||||
TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa) | ||||
SLC1A7 | Amino acid transporter. (529 aa) | ||||
IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa) | ||||
ABHD12 | Abhydrolase domain containing 12. (337 aa) | ||||
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa) | ||||
LAMP1 | Lysosomal associated membrane protein 1. (392 aa) | ||||
ITGAM | VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa) | ||||
CCL2 | C-C motif chemokine. (115 aa) | ||||
MSR1 | Macrophage scavenger receptor 1. (477 aa) | ||||
ABCG1 | ATP binding cassette subfamily G member 1. (683 aa) | ||||
LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (478 aa) | ||||
SLC1A3 | Amino acid transporter. (542 aa) | ||||
SLC1A5 | Amino acid transporter. (546 aa) | ||||
NCF1 | Neutrophil cytosolic factor 1. (368 aa) | ||||
CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa) | ||||
SLC43A2 | Solute carrier family 43 member 2. (560 aa) | ||||
SLC1A1 | Amino acid transporter. (524 aa) | ||||
ARG1 | Arginase. (352 aa) | ||||
UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (522 aa) | ||||
LYN | Tyrosine-protein kinase. (538 aa) | ||||
IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa) | ||||
IL13 | Uncharacterized protein. (132 aa) | ||||
EEA1 | Early endosome antigen 1. (1413 aa) | ||||
USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa) | ||||
TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) | ||||
SLC1A2 | Amino acid transporter. (574 aa) | ||||
CYBB | Cytochrome b-245 beta chain. (570 aa) | ||||
CD86 | Ig-like domain-containing protein. (338 aa) | ||||
PLD1 | Phospholipase. (1151 aa) | ||||
CTSS | Cathepsin S; Belongs to the peptidase C1 family. (342 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) | ||||
CD69 | CD69 molecule. (199 aa) |