STRINGSTRING
NFKBIA NFKBIA TLR1 TLR1 TLR6 TLR6 IFNG IFNG TAB2 TAB2 MAP2K7 MAP2K7 RAB7A RAB7A SOD2 SOD2 SLC1A6 SLC1A6 LMNA LMNA TLR4 TLR4 SLC1A7 SLC1A7 IL10 IL10 ABHD12 ABHD12 GAPDH GAPDH LAMP1 LAMP1 ITGAM ITGAM CCL2 CCL2 MSR1 MSR1 ABCG1 ABCG1 LPL LPL SLC1A3 SLC1A3 SLC1A5 SLC1A5 NCF1 NCF1 CYBA CYBA SLC43A2 SLC43A2 SLC1A1 SLC1A1 ARG1 ARG1 UNC93B1 UNC93B1 LYN LYN IL4 IL4 IL13 IL13 EEA1 EEA1 USP2 USP2 TAB1 TAB1 SLC1A2 SLC1A2 CYBB CYBB CD86 CD86 PLD1 PLD1 CTSS CTSS IL1B IL1B CD69 CD69
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFKBIAANK_REP_REGION domain-containing protein. (311 aa)
TLR1Toll-like receptor. (796 aa)
TLR6Toll-like receptor. (797 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP2K7Protein kinase domain-containing protein. (613 aa)
RAB7ARAS oncogene family-like 7A. (207 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
SLC1A6Amino acid transporter. (580 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (658 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
SLC1A7Amino acid transporter. (529 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
ABHD12Abhydrolase domain containing 12. (337 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
LAMP1Lysosomal associated membrane protein 1. (392 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
CCL2C-C motif chemokine. (115 aa)
MSR1Macrophage scavenger receptor 1. (477 aa)
ABCG1ATP binding cassette subfamily G member 1. (683 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (478 aa)
SLC1A3Amino acid transporter. (542 aa)
SLC1A5Amino acid transporter. (546 aa)
NCF1Neutrophil cytosolic factor 1. (368 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
SLC43A2Solute carrier family 43 member 2. (560 aa)
SLC1A1Amino acid transporter. (524 aa)
ARG1Arginase. (352 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (522 aa)
LYNTyrosine-protein kinase. (538 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
IL13Uncharacterized protein. (132 aa)
EEA1Early endosome antigen 1. (1413 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
SLC1A2Amino acid transporter. (574 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
CD86Ig-like domain-containing protein. (338 aa)
PLD1Phospholipase. (1151 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (342 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD69CD69 molecule. (199 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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