28 items (Ovis aries) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	FGFR1	Fibroblast growth factor receptor. (788 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3179 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	HORMAD1	HORMA domain containing 1. (393 aa)
	SYCP1	Synaptonemal complex protein 1. (1000 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	SYCP3	Synaptonemal complex protein 3. (225 aa)
	SRD5A1	S5A_REDUCTASE domain-containing protein. (161 aa)
	TDRD1	Uncharacterized protein. (1197 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1187 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (743 aa)
	LIFR	Uncharacterized protein. (1135 aa)
	ITGB4	Integrin beta. (1835 aa)
	HSDL2	Hydroxysteroid dehydrogenase like 2. (418 aa)
	MOV10L1	Mov10 like RISC complex RNA helicase 1. (1217 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
	HORMAD2	HORMA domain containing 2. (308 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (147 aa)
	HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
	HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4. (737 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	HORMAD1	ENSOARP00000005185	ENSOARP00000022408	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	HORMA domain containing 1.	0.666
BRCA1	HORMAD2	ENSOARP00000005185	ENSOARP00000006608	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	HORMA domain containing 2.	0.622
BRCA1	SPO11	ENSOARP00000005185	ENSOARP00000019324	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	SPO11 initiator of meiotic double stranded breaks.	0.596
BRCA1	SYCP3	ENSOARP00000005185	ENSOARP00000016365	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Synaptonemal complex protein 3.	0.523
BRCA1	TEX15	ENSOARP00000005185	ENSOARP00000000114	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Testis expressed 15, meiosis and synapsis associated.	0.414
CXCL12	CXCR4	ENSOARP00000003183	ENSOARP00000011227	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.999
CXCL12	ITGB1	ENSOARP00000003183	ENSOARP00000018925	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.523
CXCR4	CXCL12	ENSOARP00000011227	ENSOARP00000003183	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.999
CXCR4	ITGA4	ENSOARP00000011227	ENSOARP00000018121	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.434
CXCR4	ITGB1	ENSOARP00000011227	ENSOARP00000018925	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.667
CXCR4	THY1	ENSOARP00000011227	ENSOARP00000017228	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	Thy-1 cell surface antigen.	0.443
CYP7B1	HSDL2	ENSOARP00000018260	ENSOARP00000006980	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid dehydrogenase like 2.	0.538
CYP7B1	SRD5A1	ENSOARP00000018260	ENSOARP00000016053	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	S5A_REDUCTASE domain-containing protein.	0.530
FGFR1	FGFR2	ENSOARP00000001655	ENSOARP00000005775	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.930
FGFR2	FGFR1	ENSOARP00000005775	ENSOARP00000001655	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.930
HORMAD1	BRCA1	ENSOARP00000022408	ENSOARP00000005185	HORMA domain containing 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.666
HORMAD1	MOV10L1	ENSOARP00000022408	ENSOARP00000021177	HORMA domain containing 1.	Mov10 like RISC complex RNA helicase 1.	0.481
HORMAD1	SPO11	ENSOARP00000022408	ENSOARP00000019324	HORMA domain containing 1.	SPO11 initiator of meiotic double stranded breaks.	0.944
HORMAD1	SYCP1	ENSOARP00000022408	ENSOARP00000021568	HORMA domain containing 1.	Synaptonemal complex protein 1.	0.923
HORMAD1	SYCP3	ENSOARP00000022408	ENSOARP00000016365	HORMA domain containing 1.	Synaptonemal complex protein 3.	0.934