STRINGSTRING
SMURF2 SMURF2 PDE5A PDE5A PDE1B PDE1B ITGA5 ITGA5 PDE1A PDE1A AKAP9 AKAP9 SUMO1 SUMO1 CUL1 CUL1 PDE3A PDE3A SUMO3 SUMO3 UBL3 UBL3 ARRB1 ARRB1 W5PN98_SHEEP W5PN98_SHEEP PDE9A PDE9A ARRB2 ARRB2 GNB2L1 GNB2L1 PDE4D PDE4D PDE1C PDE1C GCG GCG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF2E3 ubiquitin-protein ligase. (732 aa)
PDE5APhosphodiesterase. (865 aa)
PDE1BPhosphodiesterase. (535 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
PDE1APhosphodiesterase. (514 aa)
AKAP9A-kinase anchoring protein 9. (3899 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
CUL1CULLIN_2 domain-containing protein; Belongs to the cullin family. (759 aa)
PDE3APhosphodiesterase. (829 aa)
SUMO3Small ubiquitin-related modifier. (104 aa)
UBL3Ubiquitin-like protein. (122 aa)
ARRB1Arrestin beta 1. (418 aa)
W5PN98_SHEEPSmall ubiquitin-related modifier. (95 aa)
PDE9APhosphodiesterase. (554 aa)
ARRB2Arrestin beta 2. (409 aa)
GNB2L1Guanine nucleotide-binding protein beta polypeptide 2-like 1. (317 aa)
PDE4DPhosphodiesterase. (674 aa)
PDE1CPhosphodiesterase. (657 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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