36 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FASN	Uncharacterized protein. (183 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (204 aa)
	STAT3	Signal transducer and activator of transcription. (825 aa)
	GLUD1	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
	ASL	Uncharacterized protein. (468 aa)
	OTC	Ornithine carbamoyltransferase, mitochondrial. (355 aa)
	ALDOC	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (459 aa)
	ARG2	Arginase. (354 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (359 aa)
	ALDOA	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (341 aa)
	AKR1B1	Aldo_ket_red domain-containing protein. (316 aa)
	ALDOB	Fructose-bisphosphate aldolase B. (364 aa)
	ASS1	Argininosuccinate synthase 1. (410 aa)
	FBP1	Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
	GLS2	Glutaminase 2. (602 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (566 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1149 aa)
	CS	Citrate synthase; Belongs to the citrate synthase family. (466 aa)
	LEPR	Uncharacterized protein. (1165 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	HAL	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	ACSM1	Acyl-CoA synthetase medium chain family member 1. (587 aa)
	ARG1	Arginase. (352 aa)
	JAK3	Tyrosine-protein kinase. (1091 aa)
	W5Q6U0_SHEEP	Carrier domain-containing protein. (2372 aa)
	PYCR1	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
	ACTG1	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	GLUL	Glutamine synthetase. (373 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1500 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ACSS2	ENSOARP00000019140	ENSOARP00000011568	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acyl-CoA synthetase short chain family member 2.	0.781
ACLY	ALDH7A1	ENSOARP00000019140	ENSOARP00000019693	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.	0.562
ACLY	ASL	ENSOARP00000019140	ENSOARP00000000699	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.846
ACLY	CS	ENSOARP00000019140	ENSOARP00000010102	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase; Belongs to the citrate synthase family.	0.996
ACLY	FASN	ENSOARP00000019140	ENSOARP00000003118	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.989
ACLY	FBP1	ENSOARP00000019140	ENSOARP00000009283	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...]	0.400
ACLY	FBP2	ENSOARP00000019140	ENSOARP00000009302	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family.	0.461
ACLY	GLUD1	ENSOARP00000019140	ENSOARP00000000794	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.878
ACLY	GOT1	ENSOARP00000019140	ENSOARP00000013317	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.869
ACLY	HMGCS1	ENSOARP00000019140	ENSOARP00000009315	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.899
ACLY	PC	ENSOARP00000019140	ENSOARP00000009440	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.618
ACLY	W5Q6U0_SHEEP	ENSOARP00000019140	ENSOARP00000018431	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Carrier domain-containing protein.	0.957
ACSM1	ALDH7A1	ENSOARP00000013839	ENSOARP00000019693	Acyl-CoA synthetase medium chain family member 1.	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.	0.563
ACSM1	CPS1	ENSOARP00000013839	ENSOARP00000020635	Acyl-CoA synthetase medium chain family member 1.	Carbamoyl-phosphate synthase 1.	0.525
ACSM1	CS	ENSOARP00000013839	ENSOARP00000010102	Acyl-CoA synthetase medium chain family member 1.	Citrate synthase; Belongs to the citrate synthase family.	0.759
ACSM1	FASN	ENSOARP00000013839	ENSOARP00000003118	Acyl-CoA synthetase medium chain family member 1.	Uncharacterized protein.	0.418
ACSM1	FBP2	ENSOARP00000013839	ENSOARP00000009302	Acyl-CoA synthetase medium chain family member 1.	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family.	0.424
ACSM1	GLUD1	ENSOARP00000013839	ENSOARP00000000794	Acyl-CoA synthetase medium chain family member 1.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.515
ACSM1	W5Q6U0_SHEEP	ENSOARP00000013839	ENSOARP00000018431	Acyl-CoA synthetase medium chain family member 1.	Carrier domain-containing protein.	0.418
ACSS2	ACLY	ENSOARP00000011568	ENSOARP00000019140	Acyl-CoA synthetase short chain family member 2.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.781