11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXO4	Forkhead box O4. (476 aa)
	LOC105614854	Uncharacterized protein; Belongs to the calmodulin family. (145 aa)
	FOXO6	Forkhead box O6. (414 aa)
	CALML4	Calmodulin like 4. (197 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	CALM3	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	CALML5	Calmodulin like 5. (149 aa)
	NOS1	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM3	CALML4	ENSOARP00000011414	ENSOARP00000019762	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Calmodulin like 4.	0.963
CALM3	CALML5	ENSOARP00000011414	ENSOARP00000004928	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Calmodulin like 5.	0.963
CALM3	CASP3	ENSOARP00000011414	ENSOARP00000008016	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Caspase 3; Belongs to the peptidase C14A family.	0.470
CALM3	LOC105614854	ENSOARP00000011414	ENSOARP00000022802	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Uncharacterized protein; Belongs to the calmodulin family.	0.949
CALM3	NOS1	ENSOARP00000011414	ENSOARP00000004517	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family.	0.982
CALM3	NOS2	ENSOARP00000011414	ENSOARP00000017986	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Nitric oxide synthase; Produces nitric oxide (NO).	0.976
CALM3	NOS3	ENSOARP00000011414	ENSOARP00000002091	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.865
CALML4	CALM3	ENSOARP00000019762	ENSOARP00000011414	Calmodulin like 4.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.963
CALML4	CALML5	ENSOARP00000019762	ENSOARP00000004928	Calmodulin like 4.	Calmodulin like 5.	0.966
CALML4	CASP3	ENSOARP00000019762	ENSOARP00000008016	Calmodulin like 4.	Caspase 3; Belongs to the peptidase C14A family.	0.468
CALML4	LOC105614854	ENSOARP00000019762	ENSOARP00000022802	Calmodulin like 4.	Uncharacterized protein; Belongs to the calmodulin family.	0.967
CALML4	NOS1	ENSOARP00000019762	ENSOARP00000004517	Calmodulin like 4.	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family.	0.986
CALML4	NOS2	ENSOARP00000019762	ENSOARP00000017986	Calmodulin like 4.	Nitric oxide synthase; Produces nitric oxide (NO).	0.965
CALML4	NOS3	ENSOARP00000019762	ENSOARP00000002091	Calmodulin like 4.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.806
CALML5	CALM3	ENSOARP00000004928	ENSOARP00000011414	Calmodulin like 5.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.963
CALML5	CALML4	ENSOARP00000004928	ENSOARP00000019762	Calmodulin like 5.	Calmodulin like 4.	0.966
CALML5	CASP3	ENSOARP00000004928	ENSOARP00000008016	Calmodulin like 5.	Caspase 3; Belongs to the peptidase C14A family.	0.470
CALML5	LOC105614854	ENSOARP00000004928	ENSOARP00000022802	Calmodulin like 5.	Uncharacterized protein; Belongs to the calmodulin family.	0.967
CALML5	NOS1	ENSOARP00000004928	ENSOARP00000004517	Calmodulin like 5.	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family.	0.983
CALML5	NOS2	ENSOARP00000004928	ENSOARP00000017986	Calmodulin like 5.	Nitric oxide synthase; Produces nitric oxide (NO).	0.976