STRINGSTRING
ADAMTSL2 ADAMTSL2 LEMD3 LEMD3 WNT10B WNT10B HSD17B1 HSD17B1 NAGLU NAGLU EIF4A3 EIF4A3 IFT80 IFT80 TGFB3 TGFB3 HOXD13 HOXD13 GPC6 GPC6 LTBP2 LTBP2 COL1A2 COL1A2 TMEM165 TMEM165 SGSH SGSH LRP6 LRP6 CTSK CTSK SF3B4 SF3B4 PIK3CA PIK3CA THPO THPO P3H1 P3H1 NOTCH2 NOTCH2 TCTEX1D2 TCTEX1D2 CHST14 CHST14 COL9A2 COL9A2 ZMPSTE24 ZMPSTE24 CASR CASR NRAS NRAS KRAS KRAS SMARCAL1 SMARCAL1 IDH1 IDH1 EZH2 EZH2 COL11A1 COL11A1 DNMT3A DNMT3A SMAD3 SMAD3 MAP2K1 MAP2K1 PLOD1 PLOD1 DOCK6 DOCK6 PYCR1 PYCR1 NOTUM NOTUM MATN3 MATN3 PLS3 PLS3 TRPV6 TRPV6 GNAS GNAS PHEX PHEX IFT81 IFT81 CRTAP CRTAP NEK1 NEK1 KIAA0586 KIAA0586 AIFM1 AIFM1 GNA13 GNA13 SH3BP2 SH3BP2 PAPPA2 PAPPA2 TGFBR2 TGFBR2 PITX1 PITX1 SERPINF1 SERPINF1 ENPP1 ENPP1 GALNS GALNS SUZ12 SUZ12 CA2 CA2 GC GC PORCN PORCN MANBA MANBA IDH2 IDH2 W5PQN3_SHEEP W5PQN3_SHEEP SERPINH1 SERPINH1 TGFB2 TGFB2 DNAJC21 DNAJC21 TRAPPC2B TRAPPC2B NXN NXN TGFBR1 TGFBR1 DVL2 DVL2 PLEKHM1 PLEKHM1 FGF23 FGF23 LPIN2 LPIN2 POSTN POSTN SNX10 SNX10 KYNU KYNU ORC4 ORC4 TWIST1 TWIST1 CCN6 CCN6 CDC73 CDC73 EFTUD2 EFTUD2 SPARC SPARC CC2D2A CC2D2A SFRP4 SFRP4 ALPL ALPL ARSL ARSL SLC10A7 SLC10A7 SLC25A21 SLC25A21 PAX9 PAX9 MMP9 MMP9 BGN BGN HRAS HRAS HAAO HAAO LMBR1 LMBR1 ZSWIM6 ZSWIM6 FUCA1 FUCA1 PTH1R PTH1R CYP2R1 CYP2R1 SOST SOST AMER1 AMER1 CYP27B1 CYP27B1 FLNA FLNA SETD2 SETD2 PTDSS1 PTDSS1 COL1A1 COL1A1 BHLHA9 BHLHA9 NSD1 NSD1 HGSNAT HGSNAT DHODH DHODH SMAD2 SMAD2 SULF1 SULF1 CANT1 CANT1 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAMTSL2ADAMTS like 2. (916 aa)
LEMD3LEM domain containing 3. (856 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (741 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (411 aa)
IFT80Intraflagellar transport 80. (780 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
HOXD13Homeobox D13. (291 aa)
GPC6Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (225 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1961 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
TMEM165GDT1 family protein. (256 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (622 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
SF3B4Uncharacterized protein. (424 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
THPOThrombopoietin. (353 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
NOTCH2Notch receptor 2. (2471 aa)
TCTEX1D2Uncharacterized protein. (146 aa)
CHST14Carbohydrate sulfotransferase. (373 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
CASRCalcium sensing receptor. (1032 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (514 aa)
COL11A1Collagen type XI alpha 1 chain. (1805 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (948 aa)
SMAD3Mothers against decapentaplegic homolog. (316 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (701 aa)
DOCK6Dedicator of cytokinesis 6; Belongs to the DOCK family. (2073 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (395 aa)
MATN3Matrilin 3. (489 aa)
PLS3Plastin 3. (630 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (723 aa)
GNASGNAS complex locus. (1037 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
IFT81Intraflagellar transport 81. (683 aa)
CRTAPCartilage associated protein. (400 aa)
NEK1NIMA related kinase 1. (1242 aa)
KIAA0586KIAA0586. (1553 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
GNA13G protein subunit alpha 13. (294 aa)
SH3BP2SH3 domain binding protein 2. (589 aa)
PAPPA2Pappalysin 2. (1793 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
PITX1Homeobox protein. (204 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (823 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (522 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (688 aa)
CA2Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). Reversible hydration of carbon dioxide. (263 aa)
GCGC vitamin D binding protein. (476 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (463 aa)
MANBAMannosidase beta. (880 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
W5PQN3_SHEEPUncharacterized protein. (257 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
DNAJC21DnaJ heat shock protein family (Hsp40) member C21. (534 aa)
TRAPPC2BTrafficking protein particle complex 2B. (140 aa)
NXNNucleoredoxin. (316 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (985 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (256 aa)
LPIN2Lipin 2. (889 aa)
POSTNPeriostin. (836 aa)
SNX10PX domain-containing protein. (200 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (483 aa)
TWIST1Twist family bHLH transcription factor 1. (205 aa)
CCN6Cellular communication network factor 6. (354 aa)
CDC73Cell division cycle 73. (488 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (998 aa)
SPARCKazal-like domain-containing protein. (462 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1624 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
ALPLAlkaline phosphatase. (511 aa)
ARSLArylsulfatase E. (586 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (328 aa)
SLC25A21Solute carrier family 25 member 21; Belongs to the mitochondrial carrier (TC 2.A.29) family. (269 aa)
PAX9Paired box 9. (372 aa)
MMP9Matrix metallopeptidase 9. (700 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (369 aa)
HRASHRas proto-oncogene, GTPase. (151 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (300 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (468 aa)
ZSWIM6Zinc finger SWIM-type containing 6. (1009 aa)
FUCA1Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (473 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (579 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (510 aa)
SOSTSclerostin. (209 aa)
AMER1APC membrane recruitment protein 1. (1118 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (509 aa)
FLNAFilamin A. (2633 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2556 aa)
PTDSS1Phosphatidylserine synthase 1. (485 aa)
COL1A1Collagen type I alpha 1 chain. (1474 aa)
BHLHA9Uncharacterized protein. (72 aa)
NSD1Nuclear receptor binding SET domain protein 1. (2698 aa)
HGSNATHeparan-alpha-glucosaminide N-acetyltransferase. (695 aa)
DHODHDihydroorotate dehydrogenase (quinone). (392 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
CANT1Calcium activated nucleotidase 1. (374 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (514 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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