8 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DXO	Decapping exoribonuclease. (414 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
	VARS	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (682 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	DYA	Ig-like domain-containing protein; Belongs to the MHC class II family. (318 aa)
	HSPA1A	annotation not available (643 aa)
	HSPA1A-2	Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
	W5NT24_SHEEP	Uncharacterized protein. (4129 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CD4	ENSOARP00000004039	ENSOARP00000006749	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.767
B2M	DYA	ENSOARP00000004039	ENSOARP00000007864	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.604
CD4	B2M	ENSOARP00000006749	ENSOARP00000004039	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.767
CD4	DYA	ENSOARP00000006749	ENSOARP00000007864	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.936
DXO	VARS	ENSOARP00000002474	ENSOARP00000004947	Decapping exoribonuclease.	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.616
DXO	W5NT24_SHEEP	ENSOARP00000002474	ENSOARP00000001314	Decapping exoribonuclease.	Uncharacterized protein.	0.504
DYA	B2M	ENSOARP00000007864	ENSOARP00000004039	Ig-like domain-containing protein; Belongs to the MHC class II family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.604
DYA	CD4	ENSOARP00000007864	ENSOARP00000006749	Ig-like domain-containing protein; Belongs to the MHC class II family.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.936
DYA	VARS	ENSOARP00000007864	ENSOARP00000004947	Ig-like domain-containing protein; Belongs to the MHC class II family.	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.483
DYA	W5NT24_SHEEP	ENSOARP00000007864	ENSOARP00000001314	Ig-like domain-containing protein; Belongs to the MHC class II family.	Uncharacterized protein.	0.410
HSPA1A	VARS	ENSOARP00000009461	ENSOARP00000004947	annotation not available	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.689
HSPA1A-2	VARS	ENSOARP00000009446	ENSOARP00000004947	Uncharacterized protein; Belongs to the heat shock protein 70 family.	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.672
VARS	DXO	ENSOARP00000004947	ENSOARP00000002474	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Decapping exoribonuclease.	0.616
VARS	DYA	ENSOARP00000004947	ENSOARP00000007864	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.483
VARS	HSPA1A	ENSOARP00000004947	ENSOARP00000009461	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	annotation not available	0.689
VARS	HSPA1A-2	ENSOARP00000004947	ENSOARP00000009446	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.672
VARS	W5NT24_SHEEP	ENSOARP00000004947	ENSOARP00000001314	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.598
W5NT24_SHEEP	DXO	ENSOARP00000001314	ENSOARP00000002474	Uncharacterized protein.	Decapping exoribonuclease.	0.504
W5NT24_SHEEP	DYA	ENSOARP00000001314	ENSOARP00000007864	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.410
W5NT24_SHEEP	VARS	ENSOARP00000001314	ENSOARP00000004947	Uncharacterized protein.	GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.598