STRINGSTRING
W5Q4H0_SHEEP W5Q4H0_SHEEP SPO11 SPO11 LMNB1 LMNB1 CENPA CENPA REC8 REC8 SQSTM1 SQSTM1 PXDN PXDN DDX4 DDX4 CDC42 CDC42 POU5F1 POU5F1 IL6 IL6 RAD52 RAD52 LAMP2 LAMP2 ALB ALB GLB1L2 GLB1L2 RAD50 RAD50 GLB1 GLB1 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5Q4H0_SHEEPTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (606 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
CENPAHistone domain-containing protein. (139 aa)
REC8REC8 meiotic recombination protein. (592 aa)
SQSTM1Uncharacterized protein. (445 aa)
PXDNPeroxidasin. (1368 aa)
DDX4DEAD-box helicase 4; Belongs to the DEAD box helicase family. (732 aa)
CDC42Cell division cycle 42. (237 aa)
POU5F1POU domain protein. (360 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
LAMP2Lysosomal associated membrane protein 2. (452 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
GLB1L2Beta-galactosidase. (616 aa)
RAD50Zinc-hook domain-containing protein. (1444 aa)
GLB1Beta-galactosidase. (649 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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