STRINGSTRING
CUBN CUBN CALR CALR CD55 CD55 SYNPO SYNPO IL10 IL10 NPHS1 NPHS1 LOC101102413 LOC101102413 C2 C2 CD163 CD163 ARG2 ARG2 CALR3 CALR3 HMOX1 HMOX1 NFE2L2 NFE2L2 ARG1 ARG1 ALB ALB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUBNCubilin. (3630 aa)
CALRCalreticulin. (417 aa)
CD55Uncharacterized protein. (547 aa)
SYNPOSynaptopodin. (873 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1255 aa)
LOC101102413Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (1244 aa)
CD163CD163 molecule. (1136 aa)
ARG2Arginase. (354 aa)
CALR3Calreticulin. (384 aa)
HMOX1Heme oxygenase 1. (271 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
ARG1Arginase. (352 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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