STRINGSTRING
PIK3C3 PIK3C3 HRAS HRAS GAPDH GAPDH BRD2 BRD2 CRBN CRBN ULK1 ULK1 BRAF BRAF EGFR EGFR CUL2 CUL2 SGK3 SGK3 RBX1 RBX1 NEDD8 NEDD8 KRAS KRAS NRAS NRAS HIF1A HIF1A ELOB ELOB FAM83D FAM83D BRD4 BRD4 ATG13 ATG13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa)
HRASHRas proto-oncogene, GTPase. (151 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
BRD2Bromodomain containing 2. (803 aa)
CRBNCereblon. (449 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1019 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (784 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
CUL2Cullin 2; Belongs to the cullin family. (748 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
RBX1Ring-box 1. (112 aa)
NEDD8NEDD8 ubiquitin like modifier. (77 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (841 aa)
ELOBElongin B. (118 aa)
FAM83DFamily with sequence similarity 83 member D. (577 aa)
BRD4Bromodomain containing 4. (1271 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (517 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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