STRINGSTRING
SLC6A14 SLC6A14 GLUD1 GLUD1 LOC101107259 LOC101107259 SLC38A7 SLC38A7 REN REN SPP1 SPP1 AGT AGT SLC7A6 SLC7A6 SRM SRM RHEB RHEB SLC1A6 SLC1A6 SLC38A11 SLC38A11 SLC1A7 SLC1A7 SLC3A1 SLC3A1 SHMT2 SHMT2 LOC101112287 LOC101112287 AGMAT AGMAT RICTOR RICTOR SLC38A3 SLC38A3 ATF3 ATF3 SLC1A3 SLC1A3 SLC1A5 SLC1A5 SLC7A1 SLC7A1 SLC7A5 SLC7A5 ACE2 ACE2 MAPKAP1 MAPKAP1 IGFBP1 IGFBP1 ACE ACE SLC43A2 SLC43A2 W5PU85_SHEEP W5PU85_SHEEP SLC1A1 SLC1A1 ARG1 ARG1 RPS6 RPS6 RPS6KB1 RPS6KB1 SLC2A12 SLC2A12 ODC1 ODC1 IGF1 IGF1 SLC6A19 SLC6A19 TSC2 TSC2 SLC1A2 SLC1A2 SLC7A8 SLC7A8 SLC38A4 SLC38A4 SLC38A2 SLC38A2 GSK3B GSK3B SLC1A4 SLC1A4 SLC38A6 SLC38A6 ARG2 ARG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC6A14Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (641 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
LOC101107259Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
SLC38A7Solute carrier family 38 member 7. (464 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (485 aa)
SLC7A6Solute carrier family 7 member 6. (515 aa)
SRMSpermidine synthase; Belongs to the spermidine/spermine synthase family. (221 aa)
RHEBUncharacterized protein. (168 aa)
SLC1A6Amino acid transporter. (580 aa)
SLC38A11Solute carrier family 38 member 11. (463 aa)
SLC1A7Amino acid transporter. (529 aa)
SLC3A1Solute carrier family 3 member 1. (685 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
LOC101112287PABS domain-containing protein. (365 aa)
AGMATAgmatinase; Belongs to the arginase family. (361 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1708 aa)
SLC38A3Solute carrier family 38 member 3. (472 aa)
ATF3Activating transcription factor 3. (187 aa)
SLC1A3Amino acid transporter. (542 aa)
SLC1A5Amino acid transporter. (546 aa)
SLC7A1AA_permease_C domain-containing protein. (319 aa)
SLC7A5Solute carrier family 7 member 5. (514 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] (522 aa)
IGFBP1Uncharacterized protein. (274 aa)
ACEAngiotensin-converting enzyme. (1206 aa)
SLC43A2Solute carrier family 43 member 2. (560 aa)
W5PU85_SHEEPAngiotensin-converting enzyme. (624 aa)
SLC1A1Amino acid transporter. (524 aa)
ARG1Arginase. (352 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
SLC2A12Solute carrier family 2 member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (621 aa)
ODC1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
SLC6A19Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (626 aa)
TSC2TSC complex subunit 2. (1811 aa)
SLC1A2Amino acid transporter. (574 aa)
SLC7A8Solute carrier family 7 member 8. (528 aa)
SLC38A4Solute carrier family 38 member 4. (547 aa)
SLC38A2Solute carrier family 38 member 2. (560 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
SLC1A4Solute carrier family 1 member 4. (497 aa)
SLC38A6Solute carrier family 38 member 6. (456 aa)
ARG2Arginase. (354 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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