21 items (Ovis aries) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	W5P3K5_SHEEP	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
	PXDN	Peroxidasin. (1368 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	CCL2	C-C motif chemokine. (115 aa)
	PRTN3	Proteinase 3; Belongs to the peptidase S1 family. (253 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (259 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
	CD24	Uncharacterized protein. (78 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	GC	GC vitamin D binding protein. (476 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	HPX	Hemopexin. (460 aa)
	W5QBT3_SHEEP	Glyceraldehyde-3-phosphate dehydrogenase. (327 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	LOC101102413	Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
	TLR1	Toll-like receptor. (796 aa)
	TLR6	Toll-like receptor. (797 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (147 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CXCL12	ENSOARP00000010324	ENSOARP00000003183	C-C motif chemokine.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.875
CCL2	CXCR4	ENSOARP00000010324	ENSOARP00000011227	C-C motif chemokine.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.950
CCL2	GAPDH	ENSOARP00000010324	ENSOARP00000008476	C-C motif chemokine.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.701
CCL2	IL1B	ENSOARP00000010324	ENSOARP00000022427	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.912
CCL2	IL6	ENSOARP00000010324	ENSOARP00000012891	C-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.958
CCL2	ITGAM	ENSOARP00000010324	ENSOARP00000009667	C-C motif chemokine.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.622
CCL2	PXDN	ENSOARP00000010324	ENSOARP00000005666	C-C motif chemokine.	Peroxidasin.	0.619
CCL2	TLR1	ENSOARP00000010324	ENSOARP00000000545	C-C motif chemokine.	Toll-like receptor.	0.589
CCL2	TLR2	ENSOARP00000010324	ENSOARP00000016139	C-C motif chemokine.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.717
CCL2	TLR4	ENSOARP00000010324	ENSOARP00000006210	C-C motif chemokine.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.743
CCL2	TLR6	ENSOARP00000010324	ENSOARP00000000565	C-C motif chemokine.	Toll-like receptor.	0.741
CCL2	W5P3K5_SHEEP	ENSOARP00000010324	ENSOARP00000005006	C-C motif chemokine.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.546
CCL2	W5QBT3_SHEEP	ENSOARP00000010324	ENSOARP00000020180	C-C motif chemokine.	Glyceraldehyde-3-phosphate dehydrogenase.	0.419
CD24	CXCR4	ENSOARP00000011879	ENSOARP00000011227	Uncharacterized protein.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.603
CD24	GAPDH	ENSOARP00000011879	ENSOARP00000008476	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.497
CD24	IL6	ENSOARP00000011879	ENSOARP00000012891	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.465
CD24	ITGAM	ENSOARP00000011879	ENSOARP00000009667	Uncharacterized protein.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.657
CD24	PXDN	ENSOARP00000011879	ENSOARP00000005666	Uncharacterized protein.	Peroxidasin.	0.514
CXCL12	CCL2	ENSOARP00000003183	ENSOARP00000010324	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	C-C motif chemokine.	0.875
CXCL12	CXCR4	ENSOARP00000003183	ENSOARP00000011227	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.999