STRINGSTRING
CD27 CD27 ANXA7 ANXA7 PIGR PIGR IL10 IL10 TLR4 TLR4 TG TG CD70 CD70 GSN GSN CD19 CD19 CD38 CD38 LOC101114082 LOC101114082 GLUD1 GLUD1 TLR6 TLR6 TLR1 TLR1 ANXA5 ANXA5 IL4 IL4 IL5 IL5 TLR2 TLR2 APP APP CD5 CD5 MOG MOG ANXA3 ANXA3 ANXA4 ANXA4 ANXA9 ANXA9 W5PZL5_SHEEP W5PZL5_SHEEP CCR5 CCR5 ALB ALB ANXA1 ANXA1 IL6 IL6 JCHAIN JCHAIN TLR7 TLR7 ANXA11 ANXA11 ANXA13 ANXA13 CCR9 CCR9 APOE APOE ITGAM ITGAM ANXA6 ANXA6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD27CD27 molecule. (274 aa)
ANXA7Annexin. (467 aa)
PIGRPolymeric immunoglobulin receptor. (782 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TGUncharacterized protein. (1683 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (201 aa)
GSNUncharacterized protein. (782 aa)
CD19CD19 molecule. (565 aa)
CD38Uncharacterized protein. (45 aa)
LOC101114082Annexin. (336 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
TLR6Toll-like receptor. (797 aa)
TLR1Toll-like receptor. (796 aa)
ANXA5Annexin. (339 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (133 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
CD5CD5 molecule. (495 aa)
MOGMyelin oligodendrocyte glycoprotein. (259 aa)
ANXA3Annexin. (323 aa)
ANXA4Annexin. (320 aa)
ANXA9Annexin. (361 aa)
W5PZL5_SHEEPAnnexin. (311 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
ANXA1Annexin. (346 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
JCHAINJoining chain of multimeric IgA and IgM. (159 aa)
TLR7TIR domain-containing protein. (1050 aa)
ANXA11Annexin. (570 aa)
ANXA13Annexin. (283 aa)
CCR9C-C chemokine receptor type 9; Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity); Belongs to the G-protein coupled receptor 1 family. (367 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
ANXA6Annexin. (753 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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