STRINGSTRING
SKP1 SKP1 UBR2 UBR2 RMI2 RMI2 MRI1 MRI1 NDC80 NDC80 SMC3 SMC3 CSN3 CSN3 NUF2 NUF2 MSH4 MSH4 PGK1 PGK1 REC8 REC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP1Uncharacterized protein; Belongs to the SKP1 family. (186 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1764 aa)
RMI2RecQ mediated genome instability 2. (159 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (363 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. (192 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (465 aa)
MSH4MutS homolog 4. (935 aa)
PGK1Phosphoglycerate kinase. (420 aa)
REC8REC8 meiotic recombination protein. (592 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.