(46 nodes) (2021) Transcriptome profiling analysis of the response to walnut polyphenol extract in Helicobacter pylori-infected cells. network (Ovis aries)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (286 aa)
	PLD1	Phospholipase. (1151 aa)
	RHOB	Uncharacterized protein. (208 aa)
	KLF2	Uncharacterized protein. (112 aa)
	HMOX1	Heme oxygenase 1. (271 aa)
	SMAD3	Mothers against decapentaplegic homolog. (316 aa)
	NRTN	Uncharacterized protein. (56 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	CDO1	Cysteine dioxygenase. (147 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	CXCL1	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (75 aa)
	PFKP	6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (790 aa)
	EGFR	Receptor protein-tyrosine kinase. (1155 aa)
	SGCG	Sarcoglycan gamma. (291 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (841 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	GDF15	Growth differentiation factor 15. (308 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	ADM	Adrenomedullin. (189 aa)
	SELE	Uncharacterized protein. (484 aa)
	EEF1A2	Eukaryotic translation elongation factor 1 alpha 2. (512 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
	AZU1	Azurocidin 1. (247 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (575 aa)
	ENO1	Enolase 1. (452 aa)
	PPME1	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (360 aa)
	INPP5J	Inositol polyphosphate-5-phosphatase J. (1014 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
	RASGRP2	RAS guanyl releasing protein 2. (667 aa)
	FAT1	FAT atypical cadherin 1. (4591 aa)
	CDC42	Cell division cycle 42. (237 aa)
	TNIP1	TNFAIP3 interacting protein 1. (637 aa)
	SLC25A4	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
	BLNK	B cell linker. (461 aa)
	PLD2	Phospholipase. (1068 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (607 aa)
	TPI1	Triosephosphate isomerase. (214 aa)
	NDRG1	N-myc downstream regulated 1. (414 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	ALDOA	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	MUC1	SEA domain-containing protein. (588 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	TSPAN32	Uncharacterized protein. (227 aa)
	IL6R	Interleukin 6 receptor. (422 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	STAT3	Signal transducer and activator of transcription. (825 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDOA	ENO1	ENSOARP00000004428	ENSOARP00000010235	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Enolase 1.	0.965
ALDOA	HIF1A	ENSOARP00000004428	ENSOARP00000022718	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Hypoxia inducible factor 1 subunit alpha.	0.509
ALDOA	PFKP	ENSOARP00000004428	ENSOARP00000014794	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.	0.843
ALDOA	TPI1	ENSOARP00000004428	ENSOARP00000005822	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Triosephosphate isomerase.	0.994
BIRC3	CXCL1	ENSOARP00000006810	ENSOARP00000015847	Baculoviral IAP repeat containing 3.	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	0.418
BIRC3	RELB	ENSOARP00000006810	ENSOARP00000010249	Baculoviral IAP repeat containing 3.	RELB proto-oncogene, NF-kB subunit.	0.562
BLNK	PIK3R3	ENSOARP00000007861	ENSOARP00000002301	B cell linker.	Uncharacterized protein.	0.452
BLNK	RHOB	ENSOARP00000007861	ENSOARP00000020882	B cell linker.	Uncharacterized protein.	0.463
CCR7	CXCL1	ENSOARP00000015850	ENSOARP00000015847	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	0.862
CCR7	CXCR4	ENSOARP00000015850	ENSOARP00000011227	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.805
CCR7	IL6	ENSOARP00000015850	ENSOARP00000012891	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.777
CCR7	KLF2	ENSOARP00000015850	ENSOARP00000020539	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.665
CCR7	SELE	ENSOARP00000015850	ENSOARP00000011870	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.504
CCR7	STAT3	ENSOARP00000015850	ENSOARP00000001576	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.418
CDC42	CXCR4	ENSOARP00000008675	ENSOARP00000011227	Cell division cycle 42.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.428
CDC42	EGFR	ENSOARP00000008675	ENSOARP00000014758	Cell division cycle 42.	Receptor protein-tyrosine kinase.	0.849
CDC42	KLF2	ENSOARP00000008675	ENSOARP00000020539	Cell division cycle 42.	Uncharacterized protein.	0.416
CDC42	PIK3R3	ENSOARP00000008675	ENSOARP00000002301	Cell division cycle 42.	Uncharacterized protein.	0.947
CDC42	PLD1	ENSOARP00000008675	ENSOARP00000022308	Cell division cycle 42.	Phospholipase.	0.500
CDC42	PLD2	ENSOARP00000008675	ENSOARP00000007184	Cell division cycle 42.	Phospholipase.	0.498