STRINGSTRING
JAK1 JAK1 COX1 COX1 SOCS3 SOCS3 IFNGR1 IFNGR1 TLR1 TLR1 TLR6 TLR6 MAVS MAVS IFNG IFNG TH TH SOD1-2 SOD1-2 W5P7Y3_SHEEP W5P7Y3_SHEEP SOD1 SOD1 GAPDH GAPDH UCP2 UCP2 VCL VCL PINK1 PINK1 STAT2 STAT2 W5PN98_SHEEP W5PN98_SHEEP SUMO3 SUMO3 IFNAR1 IFNAR1 IRF3 IRF3 JAK2 JAK2 STAT1 STAT1 TYK2 TYK2 SUMO1 SUMO1 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1161 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
TLR1Toll-like receptor. (796 aa)
TLR6Toll-like receptor. (797 aa)
MAVSMitochondrial antiviral signaling protein. (527 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
THTyrosine hydroxylase. (441 aa)
SOD1-2Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
W5P7Y3_SHEEPMab-21 domain-containing protein. (333 aa)
SOD1Superoxide dismutase 1. (152 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
VCLVinculin. (1069 aa)
PINK1PTEN induced kinase 1. (589 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
W5PN98_SHEEPSmall ubiquitin-related modifier. (95 aa)
SUMO3Small ubiquitin-related modifier. (104 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa)
IRF3Interferon regulatory factor 3. (411 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
TYK2Tyrosine-protein kinase. (1161 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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