15 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RSPO2	R-spondin 2. (208 aa)
	ESR2	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily. (527 aa)
	YWHAZ	14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). (247 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	HBB	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (146 aa)
	RSPO1	R-spondin 1. (262 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
	PXDN	Peroxidasin. (1368 aa)
	FOXL2	Fork-head domain-containing protein. (158 aa)
	DDX4	DEAD-box helicase 4; Belongs to the DEAD box helicase family. (732 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (300 aa)
	STRA8	Stimulated by retinoic acid 8. (366 aa)
	SOX9	SRY-box transcription factor 9. (383 aa)
	AMH	AMH_N domain-containing protein. (213 aa)
	CYP19	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (424 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	CYP19	ENSOARP00000015429	ENSOARP00000022542	AMH_N domain-containing protein.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.919
AMH	DDX4	ENSOARP00000015429	ENSOARP00000008205	AMH_N domain-containing protein.	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	0.800
AMH	ESR1	ENSOARP00000015429	ENSOARP00000003565	AMH_N domain-containing protein.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.666
AMH	ESR2	ENSOARP00000015429	ENSOARP00000022731	AMH_N domain-containing protein.	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.781
AMH	FOXL2	ENSOARP00000015429	ENSOARP00000007704	AMH_N domain-containing protein.	Fork-head domain-containing protein.	0.858
AMH	RSPO1	ENSOARP00000015429	ENSOARP00000021275	AMH_N domain-containing protein.	R-spondin 1.	0.626
AMH	SOX9	ENSOARP00000015429	ENSOARP00000014771	AMH_N domain-containing protein.	SRY-box transcription factor 9.	0.863
AMH	STRA8	ENSOARP00000015429	ENSOARP00000009039	AMH_N domain-containing protein.	Stimulated by retinoic acid 8.	0.574
AMH	WNT4	ENSOARP00000015429	ENSOARP00000008664	AMH_N domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.644
CYP19	AMH	ENSOARP00000022542	ENSOARP00000015429	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	AMH_N domain-containing protein.	0.919
CYP19	ESR1	ENSOARP00000022542	ENSOARP00000003565	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.910
CYP19	ESR2	ENSOARP00000022542	ENSOARP00000022731	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.865
CYP19	FOXL2	ENSOARP00000022542	ENSOARP00000007704	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Fork-head domain-containing protein.	0.721
CYP19	RSPO1	ENSOARP00000022542	ENSOARP00000021275	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	R-spondin 1.	0.483
CYP19	SOX9	ENSOARP00000022542	ENSOARP00000014771	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	SRY-box transcription factor 9.	0.702
CYP19	WNT4	ENSOARP00000022542	ENSOARP00000008664	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.523
DDX4	AMH	ENSOARP00000008205	ENSOARP00000015429	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	AMH_N domain-containing protein.	0.800
DDX4	FOXL2	ENSOARP00000008205	ENSOARP00000007704	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Fork-head domain-containing protein.	0.648
DDX4	SOX9	ENSOARP00000008205	ENSOARP00000014771	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	SRY-box transcription factor 9.	0.471
DDX4	SPO11	ENSOARP00000008205	ENSOARP00000019324	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	SPO11 initiator of meiotic double stranded breaks.	0.584