(6 nodes) (2021) Systematic Review of the Interaction between Nutrition and Immunity in Livestock: Effect of Dietary Supplementation with Synthetic Amino Acids. network (Ovis aries)

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Your Input:
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	ARG1	Arginase. (352 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
	ARG2	Arginase. (354 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	CD4	ENSOARP00000014964	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.899
ARG1	IL10	ENSOARP00000014964	ENSOARP00000006744	Arginase.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.907
ARG1	IL6	ENSOARP00000014964	ENSOARP00000012891	Arginase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.909
ARG1	NOS2	ENSOARP00000014964	ENSOARP00000017986	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.981
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	CD4	ENSOARP00000022756	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.758
ARG2	IL10	ENSOARP00000022756	ENSOARP00000006744	Arginase.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.860
ARG2	IL6	ENSOARP00000022756	ENSOARP00000012891	Arginase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.667
ARG2	NOS2	ENSOARP00000022756	ENSOARP00000017986	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.959
CD4	ARG1	ENSOARP00000006749	ENSOARP00000014964	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.899
CD4	ARG2	ENSOARP00000006749	ENSOARP00000022756	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.758
CD4	IL10	ENSOARP00000006749	ENSOARP00000006744	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.989
CD4	IL6	ENSOARP00000006749	ENSOARP00000012891	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.986
CD4	NOS2	ENSOARP00000006749	ENSOARP00000017986	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Nitric oxide synthase; Produces nitric oxide (NO).	0.658
IL10	ARG1	ENSOARP00000006744	ENSOARP00000014964	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Arginase.	0.907
IL10	ARG2	ENSOARP00000006744	ENSOARP00000022756	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Arginase.	0.860
IL10	CD4	ENSOARP00000006744	ENSOARP00000006749	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.989
IL10	IL6	ENSOARP00000006744	ENSOARP00000012891	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.991
IL10	NOS2	ENSOARP00000006744	ENSOARP00000017986	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Nitric oxide synthase; Produces nitric oxide (NO).	0.707