STRINGSTRING
ASPA ASPA TPP1 TPP1 LMO2 LMO2 CLN6 CLN6 ARSA ARSA SOD1 SOD1 GM2A GM2A SUMF1 SUMF1 UBE3A UBE3A IDS IDS LPL LPL DNM1 DNM1 NPY NPY MAPT MAPT CD34 CD34 CDKL5 CDKL5 HTT HTT C9orf72 C9orf72 GLB1 GLB1 MFSD8 MFSD8 CLN5 CLN5 IL2RG IL2RG IDUA IDUA NCK1 NCK1 MECP2 MECP2 CCL5 CCL5 FOXG1 FOXG1 SCN1A SCN1A SOD1-2 SOD1-2 ADA ADA CTSD CTSD GNS GNS GALC GALC CLN3 CLN3 COQ2 COQ2 NAGLU NAGLU CD38 CD38 OTC OTC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASPAAspartoacylase. (313 aa)
TPP1Tripeptidyl peptidase 1. (572 aa)
LMO2LIM domain only 2. (151 aa)
CLN6Uncharacterized protein. (299 aa)
ARSAArylsulfatase A. (507 aa)
SOD1Superoxide dismutase 1. (152 aa)
GM2AGM2 ganglioside activator. (193 aa)
SUMF1Sulfatase modifying factor 1. (299 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
IDSSulfatase domain-containing protein. (420 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (478 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (812 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (84 aa)
MAPTMicrotubule-associated protein. (771 aa)
CD34CD34 molecule. (384 aa)
CDKL5Cyclin dependent kinase like 5. (960 aa)
HTTUncharacterized protein. (3051 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
GLB1Beta-galactosidase. (649 aa)
MFSD8Major facilitator superfamily domain containing 8. (519 aa)
CLN5Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. (357 aa)
IL2RGFibronectin type-III domain-containing protein. (405 aa)
IDUAIduronidase alpha-L-. (496 aa)
NCK1Cytoplasmic protein. (377 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (482 aa)
CCL5C-C motif chemokine. (91 aa)
FOXG1Forkhead box G1. (431 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2001 aa)
SOD1-2Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
ADAAdenosine deaminase. (363 aa)
CTSDCathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. (121 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
GALCGalactosylceramidase. (690 aa)
CLN3Battenin. (438 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (294 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (741 aa)
CD38Uncharacterized protein. (45 aa)
OTCOrnithine carbamoyltransferase, mitochondrial. (355 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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