31 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MDM2	Uncharacterized protein. (499 aa)
	MAVS	Mitochondrial antiviral signaling protein. (527 aa)
	STAT3	Signal transducer and activator of transcription. (825 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	USP7	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1110 aa)
	ELOB	Elongin B. (118 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
	STAT5B	Signal transducer and activator of transcription. (791 aa)
	RBX1	Ring-box 1. (112 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (960 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (748 aa)
	CXCL10	C-X-C motif chemokine. (102 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	USP11	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (966 aa)
	TTC1	Tetratricopeptide repeat domain 1. (293 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	PLP2	Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium. (146 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1379 aa)
	NFX1	Nuclear transcription factor, X-box binding 1. (1117 aa)
	STAT2	Signal transducer and activator of transcription. (849 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	ISG15	Uncharacterized protein. (166 aa)
	TANK	TRAF family member associated NFKB activator. (458 aa)
	IRF7	Interferon regulatory factor 7. (485 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	W5P7Y3_SHEEP	Mab-21 domain-containing protein. (333 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (652 aa)
	PLP1	Proteolipid protein 1. (277 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CUL5	ENSOARP00000006749	ENSOARP00000011663	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Cullin 5; Belongs to the cullin family.	0.583
CD4	CXCL10	ENSOARP00000006749	ENSOARP00000017841	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	C-X-C motif chemokine.	0.957
CD4	ELOB	ENSOARP00000006749	ENSOARP00000000332	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Elongin B.	0.509
CD4	IFNG	ENSOARP00000006749	ENSOARP00000002060	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.985
CD4	IRAK1	ENSOARP00000006749	ENSOARP00000006297	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin 1 receptor associated kinase 1.	0.429
CD4	IRF7	ENSOARP00000006749	ENSOARP00000007094	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interferon regulatory factor 7.	0.651
CD4	ISG15	ENSOARP00000006749	ENSOARP00000007752	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Uncharacterized protein.	0.689
CD4	MAVS	ENSOARP00000006749	ENSOARP00000000974	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Mitochondrial antiviral signaling protein.	0.620
CD4	RBX1	ENSOARP00000006749	ENSOARP00000019147	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Ring-box 1.	0.917
CD4	STAT1	ENSOARP00000006749	ENSOARP00000014920	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.903
CD4	STAT2	ENSOARP00000006749	ENSOARP00000009831	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.805
CD4	STAT3	ENSOARP00000006749	ENSOARP00000001576	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.954
CD4	STAT5B	ENSOARP00000006749	ENSOARP00000020368	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.809
CD4	STAT6	ENSOARP00000006749	ENSOARP00000008144	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.942
CD4	TRAF3	ENSOARP00000006749	ENSOARP00000005336	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.594
CD4	TRAF6	ENSOARP00000006749	ENSOARP00000020492	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.687
CD4	W5P7Y3_SHEEP	ENSOARP00000006749	ENSOARP00000006537	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Mab-21 domain-containing protein.	0.670
CUL2	CUL5	ENSOARP00000018280	ENSOARP00000011663	Cullin 2; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.879
CUL2	ELOB	ENSOARP00000018280	ENSOARP00000000332	Cullin 2; Belongs to the cullin family.	Elongin B.	0.999
CUL2	ISG15	ENSOARP00000018280	ENSOARP00000007752	Cullin 2; Belongs to the cullin family.	Uncharacterized protein.	0.591