21 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SQSTM1	Uncharacterized protein. (445 aa)
	ELOB	Elongin B. (118 aa)
	PINK1	PTEN induced kinase 1. (589 aa)
	ACTG1	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	RBX1	Ring-box 1. (112 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (748 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	RNF34	Ring finger protein 34. (375 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	IRF3	Interferon regulatory factor 3. (411 aa)
	IFNAR1	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	CCL2	C-C motif chemokine. (115 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (954 aa)
	ISG15	Uncharacterized protein. (166 aa)
	STAT2	Signal transducer and activator of transcription. (849 aa)
	ELOC	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (249 aa)
	ZYG11B	Zyg-11 family member B, cell cycle regulator. (737 aa)
	IRF5	Interferon regulatory factor 5. (499 aa)
	TOMM20	Uncharacterized protein. (104 aa)
	MAVS	Mitochondrial antiviral signaling protein. (527 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CCL2	ENSOARP00000013345	ENSOARP00000010324	Angiotensin-converting enzyme.	C-C motif chemokine.	0.536
ACTG1	CCL2	ENSOARP00000019868	ENSOARP00000010324	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	C-C motif chemokine.	0.524
ACTG1	IRF3	ENSOARP00000019868	ENSOARP00000014293	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interferon regulatory factor 3.	0.573
ACTG1	ISG15	ENSOARP00000019868	ENSOARP00000007752	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.520
ACTG1	MAVS	ENSOARP00000019868	ENSOARP00000000974	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mitochondrial antiviral signaling protein.	0.433
ACTG1	RBX1	ENSOARP00000019868	ENSOARP00000019147	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Ring-box 1.	0.400
ACTG1	SQSTM1	ENSOARP00000019868	ENSOARP00000002847	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.449
ACTG1	STAT1	ENSOARP00000019868	ENSOARP00000014920	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Signal transducer and activator of transcription.	0.527
ACTG1	STAT2	ENSOARP00000019868	ENSOARP00000009831	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Signal transducer and activator of transcription.	0.402
CCL2	ACE2	ENSOARP00000010324	ENSOARP00000013345	C-C motif chemokine.	Angiotensin-converting enzyme.	0.536
CCL2	ACTG1	ENSOARP00000010324	ENSOARP00000019868	C-C motif chemokine.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.524
CCL2	IFNAR1	ENSOARP00000010324	ENSOARP00000014132	C-C motif chemokine.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.454
CCL2	IRF1	ENSOARP00000010324	ENSOARP00000016180	C-C motif chemokine.	Interferon regulatory factor.	0.529
CCL2	IRF3	ENSOARP00000010324	ENSOARP00000014293	C-C motif chemokine.	Interferon regulatory factor 3.	0.456
CCL2	IRF5	ENSOARP00000010324	ENSOARP00000004174	C-C motif chemokine.	Interferon regulatory factor 5.	0.497
CCL2	ISG15	ENSOARP00000010324	ENSOARP00000007752	C-C motif chemokine.	Uncharacterized protein.	0.606
CCL2	STAT1	ENSOARP00000010324	ENSOARP00000014920	C-C motif chemokine.	Signal transducer and activator of transcription.	0.479
CCL2	STAT2	ENSOARP00000010324	ENSOARP00000009831	C-C motif chemokine.	Signal transducer and activator of transcription.	0.454
CUL2	ELOB	ENSOARP00000018280	ENSOARP00000000332	Cullin 2; Belongs to the cullin family.	Elongin B.	0.999
CUL2	ELOC	ENSOARP00000018280	ENSOARP00000006740	Cullin 2; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.999