17 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TET2	Tet methylcytosine dioxygenase 2. (2020 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1733 aa)
	SALL4	Spalt like transcription factor 4. (1004 aa)
	SOX9	SRY-box transcription factor 9. (383 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	TGFA	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
	DAZL	Deleted in azoospermia like. (258 aa)
	PAX7	Paired box 7. (501 aa)
	STRA8	Stimulated by retinoic acid 8. (366 aa)
	FOXO1	Fork-head domain-containing protein. (445 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2138 aa)
	BMI1	RING-type domain-containing protein. (326 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (948 aa)
	GFRA1	GDNF family receptor alpha 1. (335 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	DNMT1	ENSOARP00000001527	ENSOARP00000016508	RING-type domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.620
BMI1	PAX7	ENSOARP00000001527	ENSOARP00000011364	RING-type domain-containing protein.	Paired box 7.	0.419
BMI1	SALL4	ENSOARP00000001527	ENSOARP00000015631	RING-type domain-containing protein.	Spalt like transcription factor 4.	0.511
BMI1	SOX9	ENSOARP00000001527	ENSOARP00000014771	RING-type domain-containing protein.	SRY-box transcription factor 9.	0.477
DAZL	DMC1	ENSOARP00000016597	ENSOARP00000016725	Deleted in azoospermia like.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.622
DAZL	GFRA1	ENSOARP00000016597	ENSOARP00000017371	Deleted in azoospermia like.	GDNF family receptor alpha 1.	0.654
DAZL	NANOS2	ENSOARP00000016597	ENSOARP00000012291	Deleted in azoospermia like.	Nanos C2HC-type zinc finger 2; Belongs to the nanos family.	0.857
DAZL	REC8	ENSOARP00000016597	ENSOARP00000020623	Deleted in azoospermia like.	REC8 meiotic recombination protein.	0.610
DAZL	SALL4	ENSOARP00000016597	ENSOARP00000015631	Deleted in azoospermia like.	Spalt like transcription factor 4.	0.572
DAZL	STRA8	ENSOARP00000016597	ENSOARP00000009039	Deleted in azoospermia like.	Stimulated by retinoic acid 8.	0.872
DMC1	DAZL	ENSOARP00000016725	ENSOARP00000016597	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Deleted in azoospermia like.	0.622
DMC1	NANOS2	ENSOARP00000016725	ENSOARP00000012291	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Nanos C2HC-type zinc finger 2; Belongs to the nanos family.	0.418
DMC1	REC8	ENSOARP00000016725	ENSOARP00000020623	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	REC8 meiotic recombination protein.	0.921
DMC1	STRA8	ENSOARP00000016725	ENSOARP00000009039	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Stimulated by retinoic acid 8.	0.573
DNMT1	BMI1	ENSOARP00000016508	ENSOARP00000001527	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	RING-type domain-containing protein.	0.620
DNMT1	DNMT3A	ENSOARP00000016508	ENSOARP00000019641	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.997
DNMT1	TET1	ENSOARP00000016508	ENSOARP00000005514	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 1.	0.776
DNMT1	TET2	ENSOARP00000016508	ENSOARP00000011407	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.765
DNMT3A	DNMT1	ENSOARP00000019641	ENSOARP00000016508	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.997
DNMT3A	SALL4	ENSOARP00000019641	ENSOARP00000015631	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Spalt like transcription factor 4.	0.493