22 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (841 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (685 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2595 aa)
	PARD3B	Par-3 family cell polarity regulator beta. (1025 aa)
	LNPEP	Leucyl and cystinyl aminopeptidase. (1026 aa)
	EP300	E1A binding protein p300. (2428 aa)
	FTO	FTO_NTD domain-containing protein. (505 aa)
	PDE11A	Phosphodiesterase. (914 aa)
	KIF6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (809 aa)
	PDE5A	Phosphodiesterase. (865 aa)
	CCR3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)
	PXN	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (589 aa)
	ANPEP	Aminopeptidase. (968 aa)
	RAI14	Retinoic acid induced 14. (1024 aa)
	PTCH1	Patched 1. (1450 aa)
	AKAP1	A-kinase anchoring protein 1. (767 aa)
	GRB14	Growth factor receptor bound protein 14. (540 aa)
	TG	Uncharacterized protein. (1683 aa)
	PDE10A	Phosphodiesterase. (791 aa)
	ENPEP	Aminopeptidase. (953 aa)
	REN	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	GRB14	ENSOARP00000020725	ENSOARP00000006261	ATP binding cassette subfamily A member 12.	Growth factor receptor bound protein 14.	0.496
ABCA12	ZBTB20	ENSOARP00000020725	ENSOARP00000021072	ATP binding cassette subfamily A member 12.	Zinc finger and BTB domain containing 20.	0.419
AKAP1	EDN1	ENSOARP00000008188	ENSOARP00000015104	A-kinase anchoring protein 1.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.400
AKAP1	PARD3B	ENSOARP00000008188	ENSOARP00000019728	A-kinase anchoring protein 1.	Par-3 family cell polarity regulator beta.	0.543
AKAP1	PDE11A	ENSOARP00000008188	ENSOARP00000018664	A-kinase anchoring protein 1.	Phosphodiesterase.	0.476
ANPEP	ENPEP	ENSOARP00000012699	ENSOARP00000003978	Aminopeptidase.	Aminopeptidase.	0.438
ANPEP	REN	ENSOARP00000012699	ENSOARP00000002426	Aminopeptidase.	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	0.611
EDN1	AKAP1	ENSOARP00000015104	ENSOARP00000008188	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	A-kinase anchoring protein 1.	0.400
EDN1	HIF1A	ENSOARP00000015104	ENSOARP00000022718	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Hypoxia inducible factor 1 subunit alpha.	0.589
EDN1	PDE5A	ENSOARP00000015104	ENSOARP00000017204	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Phosphodiesterase.	0.466
EDN1	REN	ENSOARP00000015104	ENSOARP00000002426	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	0.913
ENPEP	ANPEP	ENSOARP00000003978	ENSOARP00000012699	Aminopeptidase.	Aminopeptidase.	0.438
ENPEP	REN	ENSOARP00000003978	ENSOARP00000002426	Aminopeptidase.	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	0.620
EP300	HIF1A	ENSOARP00000019268	ENSOARP00000022718	E1A binding protein p300.	Hypoxia inducible factor 1 subunit alpha.	0.998
EP300	ZBTB20	ENSOARP00000019268	ENSOARP00000021072	E1A binding protein p300.	Zinc finger and BTB domain containing 20.	0.430
FTO	GRB14	ENSOARP00000019255	ENSOARP00000006261	FTO_NTD domain-containing protein.	Growth factor receptor bound protein 14.	0.406
GRB14	ABCA12	ENSOARP00000006261	ENSOARP00000020725	Growth factor receptor bound protein 14.	ATP binding cassette subfamily A member 12.	0.496
GRB14	FTO	ENSOARP00000006261	ENSOARP00000019255	Growth factor receptor bound protein 14.	FTO_NTD domain-containing protein.	0.406
GRB14	ZBTB20	ENSOARP00000006261	ENSOARP00000021072	Growth factor receptor bound protein 14.	Zinc finger and BTB domain containing 20.	0.403
HIF1A	EDN1	ENSOARP00000022718	ENSOARP00000015104	Hypoxia inducible factor 1 subunit alpha.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.589