(13 nodes) (2022) Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. network (Ovis aries)

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Your Input:
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2409 aa)
	CTTN	Cortactin. (511 aa)
	PIEZO2	Piezo-type mechanosensitive ion channel component. (2740 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1101 aa)
	PXDN	Peroxidasin. (1368 aa)
	TRPC6	Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (765 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	EMCN	Endomucin. (234 aa)
	ICAM1	Ig-like domain-containing protein. (536 aa)
	SRC	Tyrosine-protein kinase. (541 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (486 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTTN	GAPDH	ENSOARP00000000465	ENSOARP00000008476	Cortactin.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.479
CTTN	HCLS1	ENSOARP00000000465	ENSOARP00000021530	Cortactin.	Hematopoietic cell-specific Lyn substrate 1.	0.921
CTTN	ICAM1	ENSOARP00000000465	ENSOARP00000016801	Cortactin.	Ig-like domain-containing protein.	0.441
CTTN	PTK2	ENSOARP00000000465	ENSOARP00000003657	Cortactin.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.714
CTTN	PXDN	ENSOARP00000000465	ENSOARP00000005666	Cortactin.	Peroxidasin.	0.421
CTTN	SRC	ENSOARP00000000465	ENSOARP00000019257	Cortactin.	Tyrosine-protein kinase.	0.985
GAPDH	CTTN	ENSOARP00000008476	ENSOARP00000000465	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Cortactin.	0.479
GAPDH	HCLS1	ENSOARP00000008476	ENSOARP00000021530	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Hematopoietic cell-specific Lyn substrate 1.	0.473
GAPDH	ICAM1	ENSOARP00000008476	ENSOARP00000016801	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Ig-like domain-containing protein.	0.664
GAPDH	IL1B	ENSOARP00000008476	ENSOARP00000022427	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.888
GAPDH	ITGAM	ENSOARP00000008476	ENSOARP00000009667	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.654
GAPDH	PTK2	ENSOARP00000008476	ENSOARP00000003657	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.535
GAPDH	PXDN	ENSOARP00000008476	ENSOARP00000005666	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Peroxidasin.	0.919
GAPDH	SRC	ENSOARP00000008476	ENSOARP00000019257	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Tyrosine-protein kinase.	0.712
HCLS1	CTTN	ENSOARP00000021530	ENSOARP00000000465	Hematopoietic cell-specific Lyn substrate 1.	Cortactin.	0.921
HCLS1	GAPDH	ENSOARP00000021530	ENSOARP00000008476	Hematopoietic cell-specific Lyn substrate 1.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.473
HCLS1	PTK2	ENSOARP00000021530	ENSOARP00000003657	Hematopoietic cell-specific Lyn substrate 1.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.532
HCLS1	PXDN	ENSOARP00000021530	ENSOARP00000005666	Hematopoietic cell-specific Lyn substrate 1.	Peroxidasin.	0.426
HCLS1	SRC	ENSOARP00000021530	ENSOARP00000019257	Hematopoietic cell-specific Lyn substrate 1.	Tyrosine-protein kinase.	0.983
ICAM1	CTTN	ENSOARP00000016801	ENSOARP00000000465	Ig-like domain-containing protein.	Cortactin.	0.441