13 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELOB	Elongin B. (118 aa)
	ACTB	Actin, cytoplasmic 1. (378 aa)
	W5P3B7_SHEEP	Uncharacterized protein. (408 aa)
	ELOA	Elongin A. (762 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	CDK12	Cyclin dependent kinase 12. (1481 aa)
	USP2	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (748 aa)
	RBX1	Ring-box 1. (112 aa)
	ACTG1	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	BARD1	BRCA1 associated RING domain 1. (780 aa)
	USP3	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (520 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	GAPDH	ENSOARP00000003215	ENSOARP00000008476	Actin, cytoplasmic 1.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.927
ACTG1	GAPDH	ENSOARP00000019868	ENSOARP00000008476	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.936
ACTG1	RBX1	ENSOARP00000019868	ENSOARP00000019147	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Ring-box 1.	0.400
CDK12	ELOA	ENSOARP00000012031	ENSOARP00000007759	Cyclin dependent kinase 12.	Elongin A.	0.459
CDK12	W5P3B7_SHEEP	ENSOARP00000012031	ENSOARP00000004917	Cyclin dependent kinase 12.	Uncharacterized protein.	0.724
CUL2	CUL5	ENSOARP00000018280	ENSOARP00000011663	Cullin 2; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.879
CUL2	ELOB	ENSOARP00000018280	ENSOARP00000000332	Cullin 2; Belongs to the cullin family.	Elongin B.	0.999
CUL2	RBX1	ENSOARP00000018280	ENSOARP00000019147	Cullin 2; Belongs to the cullin family.	Ring-box 1.	0.999
CUL5	CUL2	ENSOARP00000011663	ENSOARP00000018280	Cullin 5; Belongs to the cullin family.	Cullin 2; Belongs to the cullin family.	0.879
CUL5	ELOA	ENSOARP00000011663	ENSOARP00000007759	Cullin 5; Belongs to the cullin family.	Elongin A.	0.650
CUL5	ELOB	ENSOARP00000011663	ENSOARP00000000332	Cullin 5; Belongs to the cullin family.	Elongin B.	0.999
CUL5	RBX1	ENSOARP00000011663	ENSOARP00000019147	Cullin 5; Belongs to the cullin family.	Ring-box 1.	0.999
ELOA	CDK12	ENSOARP00000007759	ENSOARP00000012031	Elongin A.	Cyclin dependent kinase 12.	0.459
ELOA	CUL5	ENSOARP00000007759	ENSOARP00000011663	Elongin A.	Cullin 5; Belongs to the cullin family.	0.650
ELOA	ELOB	ENSOARP00000007759	ENSOARP00000000332	Elongin A.	Elongin B.	0.946
ELOB	CUL2	ENSOARP00000000332	ENSOARP00000018280	Elongin B.	Cullin 2; Belongs to the cullin family.	0.999
ELOB	CUL5	ENSOARP00000000332	ENSOARP00000011663	Elongin B.	Cullin 5; Belongs to the cullin family.	0.999
ELOB	ELOA	ENSOARP00000000332	ENSOARP00000007759	Elongin B.	Elongin A.	0.946
ELOB	RBX1	ENSOARP00000000332	ENSOARP00000019147	Elongin B.	Ring-box 1.	0.999
GAPDH	ACTB	ENSOARP00000008476	ENSOARP00000003215	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Actin, cytoplasmic 1.	0.927