11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD40	CD40 molecule. (280 aa)
	CD163	CD163 molecule. (1136 aa)
	LOC101102413	Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	CD4	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
	SELP	P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. (769 aa)
	ARG1	Arginase. (352 aa)
	SPIC	Spi-C transcription factor. (247 aa)
	HPX	Hemopexin. (460 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
	ARG2	Arginase. (354 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	CD163	ENSOARP00000014964	ENSOARP00000003050	Arginase.	CD163 molecule.	0.801
ARG1	CD4	ENSOARP00000014964	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.899
ARG1	CD40	ENSOARP00000014964	ENSOARP00000008975	Arginase.	CD40 molecule.	0.442
ARG1	CSF1	ENSOARP00000014964	ENSOARP00000020785	Arginase.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.608
ARG1	TLR4	ENSOARP00000014964	ENSOARP00000006210	Arginase.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.615
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	CD163	ENSOARP00000022756	ENSOARP00000003050	Arginase.	CD163 molecule.	0.590
ARG2	CD4	ENSOARP00000022756	ENSOARP00000006749	Arginase.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.758
ARG2	TLR4	ENSOARP00000022756	ENSOARP00000006210	Arginase.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.436
CD163	ARG1	ENSOARP00000003050	ENSOARP00000014964	CD163 molecule.	Arginase.	0.801
CD163	ARG2	ENSOARP00000003050	ENSOARP00000022756	CD163 molecule.	Arginase.	0.590
CD163	CD4	ENSOARP00000003050	ENSOARP00000006749	CD163 molecule.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.867
CD163	CD40	ENSOARP00000003050	ENSOARP00000008975	CD163 molecule.	CD40 molecule.	0.565
CD163	CSF1	ENSOARP00000003050	ENSOARP00000020785	CD163 molecule.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.769
CD163	HPX	ENSOARP00000003050	ENSOARP00000019654	CD163 molecule.	Hemopexin.	0.520
CD163	LOC101102413	ENSOARP00000003050	ENSOARP00000004002	CD163 molecule.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.967
CD163	TLR4	ENSOARP00000003050	ENSOARP00000006210	CD163 molecule.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.737
CD4	ARG1	ENSOARP00000006749	ENSOARP00000014964	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.899
CD4	ARG2	ENSOARP00000006749	ENSOARP00000022756	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Arginase.	0.758